一个组织特异性抵抗素样分子家族。
A family of tissue-specific resistin-like molecules.
作者信息
Steppan C M, Brown E J, Wright C M, Bhat S, Banerjee R R, Dai C Y, Enders G H, Silberg D G, Wen X, Wu G D, Lazar M A
机构信息
Division of Endocrinology, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):502-6. doi: 10.1073/pnas.98.2.502.
Abstract
We have identified a family of resistin-like molecules (RELMs) in rodents and humans. Resistin is a hormone produced by fat cells. RELMalpha is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue. Another family member, RELMbeta, is a secreted protein expressed only in the gastrointestinal tract, particularly the colon, in both mouse and human. RELMbeta gene expression is highest in proliferative epithelial cells and is markedly increased in tumors, suggesting a role in intestinal proliferation. Resistin and the RELMs share a cysteine composition and other signature features. Thus, the RELMs together with resistin comprise a class of tissue-specific signaling molecules.
摘要
我们在啮齿动物和人类中鉴定出了一个抵抗素样分子（RELM）家族。抵抗素是一种由脂肪细胞产生的激素。RELMα是一种分泌蛋白，其组织分布有限，在脂肪组织中水平最高。另一个家族成员RELMβ是一种仅在小鼠和人类的胃肠道，特别是结肠中表达的分泌蛋白。RELMβ基因在增殖上皮细胞中表达最高，且在肿瘤中显著增加，提示其在肠道增殖中发挥作用。抵抗素和RELM家族成员具有共同的半胱氨酸组成和其他标志性特征。因此，RELM家族与抵抗素共同构成了一类组织特异性信号分子。
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