• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

TIMD4-MHCⅡ巨噬细胞通过Retnla维持心脏功能。

TIMD4MHCⅡ Macrophages Preserve Heart Function Through Retnla.

作者信息

Zhang Danyang, Wang Xuanhao, Zhu Lianlian, Chen Yuxing, Yang Chao, Zhong Zhiwei, Kong Xiangming, Nan Jinliang, Wang Chen, Hu Hengxun, Chen Jinghai, Shi Peng, Hu Xinyang, Zhu Wei, Wang Jian'an

机构信息

Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

State Key Laboratory of Transvascular Implantation Devices, Hangzhou, Zhejiang, China.

出版信息

JACC Basic Transl Sci. 2024 Nov 6;10(1):65-84. doi: 10.1016/j.jacbts.2024.08.009. eCollection 2025 Jan.

DOI:10.1016/j.jacbts.2024.08.009
PMID:39906591
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11788475/
Abstract

Genetic fate mapping confirmed the existence of the TIMD4MHCⅡ macrophage subset and showed that they were resident macrophages with minimal input from peripheral monocytes. Further, single-cell RNA sequencing revealed that could serve as the signature gene for TIMD4MHCⅡ macrophages. Administration of recombinant protein of the gene, RELMα, delayed the onset of heart failure, whereas either deletion of TIMD4MHCⅡ macrophages or macrophage-specific loss of facilitated heart failure progression.

摘要

遗传命运图谱证实了TIMD4MHCⅡ巨噬细胞亚群的存在，并表明它们是驻留巨噬细胞，外周单核细胞的输入极少。此外，单细胞RNA测序显示， 可作为TIMD4MHCⅡ巨噬细胞的特征基因。给予该基因的重组蛋白RELMα可延迟心力衰竭的发作，而删除TIMD4MHCⅡ巨噬细胞或巨噬细胞特异性缺失 则会促进心力衰竭的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/03bc188f5c44/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/ff91c7c1de63/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/93bea77cf735/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/a6cd48a0b939/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/2a641f7153c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/d1eb0de3156c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/2d828d02744b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/9544aba76ef0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/03bc188f5c44/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/ff91c7c1de63/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/93bea77cf735/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/a6cd48a0b939/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/2a641f7153c1/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/d1eb0de3156c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/2d828d02744b/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/9544aba76ef0/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4b55/11788475/03bc188f5c44/gr7.jpg

相似文献

1
TIMD4MHCⅡ Macrophages Preserve Heart Function Through Retnla.TIMD4-MHCⅡ巨噬细胞通过Retnla维持心脏功能。
JACC Basic Transl Sci. 2024 Nov 6;10(1):65-84. doi: 10.1016/j.jacbts.2024.08.009. eCollection 2025 Jan.
2
Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction.心肌梗死后，自我更新的驻留心肌巨噬细胞限制了不良重构。
Nat Immunol. 2019 Jan;20(1):29-39. doi: 10.1038/s41590-018-0272-2. Epub 2018 Dec 11.
3
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.三种组织驻留巨噬细胞亚群存在于器官中，具有保守的起源和生命周期。
Sci Immunol. 2022 Jan 7;7(67):eabf7777. doi: 10.1126/sciimmunol.abf7777.
4
Mineralocorticoid receptor promotes cardiac macrophage inflammaging.醛固酮受体促进心脏巨噬细胞炎症老化。
Basic Res Cardiol. 2024 Apr;119(2):243-260. doi: 10.1007/s00395-024-01032-6. Epub 2024 Feb 8.
5
Comparison of RELMα and RELMβ Single- and Double-Gene-Deficient Mice Reveals that RELMα Expression Dictates Inflammation and Worm Expulsion in Hookworm Infection.RELMα和RELMβ单基因及双基因缺陷小鼠的比较表明，RELMα的表达决定了钩虫感染中的炎症反应和蠕虫排出。
Infect Immun. 2016 Mar 24;84(4):1100-1111. doi: 10.1128/IAI.01479-15. Print 2016 Apr.
6
TREM2 resident macrophages protect the septic heart by maintaining cardiomyocyte homeostasis.TREM2 固有巨噬细胞通过维持心肌细胞的稳态来保护脓毒症心脏。
Nat Metab. 2023 Jan;5(1):129-146. doi: 10.1038/s42255-022-00715-5. Epub 2023 Jan 12.
7
Two distinct resident macrophage populations coexist in the ovary.卵巢中存在两种不同的驻留巨噬细胞群体。
Front Immunol. 2022 Dec 20;13:1007711. doi: 10.3389/fimmu.2022.1007711. eCollection 2022.
8
Lung disease in relation to unique monocyte-macrophage subpopulations induced by combined inhalant endotoxin and collagen-induced arthritis.与联合吸入内毒素和胶原诱导性关节炎所诱导的独特单核细胞-巨噬细胞亚群相关的肺部疾病
Front Immunol. 2025 Apr 9;16:1557583. doi: 10.3389/fimmu.2025.1557583. eCollection 2025.
9
Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma.肿瘤特异性 CD4 T 细胞在胰腺导管腺癌中指导单核细胞命运。
Cell Rep. 2023 Jul 25;42(7):112732. doi: 10.1016/j.celrep.2023.112732. Epub 2023 Jul 3.
10
Choline metabolism underpins macrophage IL-4 polarization and RELMα up-regulation in helminth infection.胆碱代谢为寄生虫感染中巨噬细胞 IL-4 极化和 RELMα 的上调提供支持。
PLoS Pathog. 2023 Sep 25;19(9):e1011658. doi: 10.1371/journal.ppat.1011658. eCollection 2023 Sep.

引用本文的文献

1
Omics-based Approach Towards Macrophages: New Perspectives of Biology and Function in the Normal and Diseased Heart.基于组学的巨噬细胞研究方法：正常和患病心脏中生物学与功能的新视角
Int J Biol Sci. 2025 May 27;21(8):3666-3688. doi: 10.7150/ijbs.112061. eCollection 2025.
2
Precision Targeting of Cardiac Macrophage Subsets to Ameliorate Heart Failure.精准靶向心脏巨噬细胞亚群以改善心力衰竭
JACC Basic Transl Sci. 2025 Jan 27;10(1):85-87. doi: 10.1016/j.jacbts.2024.10.013. eCollection 2025 Jan.

本文引用的文献

1
Assessing Potential Risks of Future Redo Transcatheter Aortic Valve Replacement in Asian Patients.评估亚洲患者未来再次经导管主动脉瓣置换术的潜在风险。
JACC Asia. 2023 Oct 31;4(1):25-39. doi: 10.1016/j.jacasi.2023.09.004. eCollection 2024 Jan.
2
Three tissue resident macrophage subsets coexist across organs with conserved origins and life cycles.三种组织驻留巨噬细胞亚群存在于器官中，具有保守的起源和生命周期。
Sci Immunol. 2022 Jan 7;7(67):eabf7777. doi: 10.1126/sciimmunol.abf7777.
3
Efferocytosis induces macrophage proliferation to help resolve tissue injury.
吞噬作用可诱导巨噬细胞增殖，以帮助组织损伤修复。
Cell Metab. 2021 Dec 7;33(12):2445-2463.e8. doi: 10.1016/j.cmet.2021.10.015. Epub 2021 Nov 15.
4
Cardiac Resident Macrophages Prevent Fibrosis and Stimulate Angiogenesis.心肌 Resident 巨噬细胞可预防纤维化并刺激血管生成。
Circ Res. 2021 Dec 3;129(12):1086-1101. doi: 10.1161/CIRCRESAHA.121.319737. Epub 2021 Oct 14.
5
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress.选择性缺失驻留巨噬细胞衍生的胰岛素样生长因子-1 可消除应激时的适应性心脏生长。
Immunity. 2021 Sep 14;54(9):2057-2071.e6. doi: 10.1016/j.immuni.2021.07.006. Epub 2021 Aug 6.
6
Trichuris muris infection drives cell-intrinsic IL4R alpha independent colonic RELMα+ macrophages.感染旋毛虫可诱导内在的 IL4Rα 独立的结肠 RELMα+巨噬细胞。
PLoS Pathog. 2021 Jul 30;17(7):e1009768. doi: 10.1371/journal.ppat.1009768. eCollection 2021 Jul.
7
Resident cardiac macrophages mediate adaptive myocardial remodeling.心肌内固有巨噬细胞介导电感性心肌重构。
Immunity. 2021 Sep 14;54(9):2072-2088.e7. doi: 10.1016/j.immuni.2021.07.003. Epub 2021 Jul 27.
8
HIMF deletion ameliorates acute myocardial ischemic injury by promoting macrophage transformation to reparative subtype.HIMF 缺失通过促进巨噬细胞向修复亚型转化来改善急性心肌缺血性损伤。
Basic Res Cardiol. 2021 Apr 23;116(1):30. doi: 10.1007/s00395-021-00867-7.
9
The Role of Hypoxia-Induced Mitogenic Factor in Organ-Specific Inflammation in the Lung and Liver: Key Concepts and Gaps in Knowledge Regarding Molecular Mechanisms of Acute or Immune-Mediated Liver Injury.缺氧诱导有丝分裂因子在肺和肝的器官特异性炎症中的作用：急性或免疫介导的肝损伤分子机制的关键概念和知识空白。
Int J Mol Sci. 2021 Mar 8;22(5):2717. doi: 10.3390/ijms22052717.
10
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart.巨噬细胞网络支持心脏中线粒体的稳态。
Cell. 2020 Oct 1;183(1):94-109.e23. doi: 10.1016/j.cell.2020.08.031. Epub 2020 Sep 15.