Janes Kali, Neumann William L, Salvemini Daniela
Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St. Louis, MO 63104, USA.
Biochim Biophys Acta. 2012 May;1822(5):815-21. doi: 10.1016/j.bbadis.2011.12.008. Epub 2011 Dec 19.
Superoxide (SO, O(2)·(-)) and its reaction product peroxynitrite (PN, ONOO(-)) have been shown to be important in the development of pain of several etiologies. While significant progress has been made in teasing out the relative contribution of SO and PN peripherally, spinally, and supraspinally during the development and maintenance of central sensitization and pain, there is still a considerable void in our understanding. Further research is required in order to develop improved therapeutic strategies for selectively eliminating SO and/or PN. Furthermore, it may be that PN is a more attractive target, in that unlike SO it has no currently known beneficial role. Our group has been at the forefront of research concerning the role of SO and PN in pain, and our current findings have led to the development of two new classes of orally active catalysts which are selective for PN decomposition while sparing SO. This article is part of a Special Issue entitled: Antioxidants and Antioxidant Treatment in Disease.
超氧阴离子（SO，O₂·⁻）及其反应产物过氧亚硝酸盐（PN，ONOO⁻）已被证明在多种病因引起的疼痛发展中起重要作用。虽然在梳理SO和PN在中枢敏化和疼痛的发展及维持过程中在周围、脊髓和脊髓上的相对贡献方面已取得显著进展，但我们的理解仍存在相当大的空白。为了开发出选择性消除SO和/或PN的改进治疗策略，还需要进一步研究。此外，PN可能是一个更具吸引力的靶点，因为与SO不同，目前尚未发现它有任何有益作用。我们的团队一直处于关于SO和PN在疼痛中作用的研究前沿，我们目前的研究结果已导致开发出两类新型口服活性催化剂，它们对PN分解具有选择性，同时保留SO。本文是名为：疾病中的抗氧化剂和抗氧化治疗的特刊的一部分。
