Inwald D, Davies E G, Klein N
Portex Department of Anaesthesia, Intensive Care and Respiratory Medicine, Institute of Child Health, London, UK.
Mol Pathol. 2001 Feb;54(1):1-7. doi: 10.1136/mp.54.1.1.
The basic physiology of leucocyte emigration from the intravascular space into the tissues is now known to be dependent on a class of cell surface molecules that have come to be known as adhesion molecules. Many cell-cell interactions are dependent on adhesion and signal transduction via the various adhesion molecules, particularly the integrins. The study of the functions of these molecules has been enhanced by the development of blocking and activating monoclonal antibodies, knockout mice, and by the rare "experiments of nature" in the human population, in whom there is absence or dysfunction of one of the adhesion molecules. This review describes these leucocyte adhesion defects and discusses how they have provided important insights into the function of these molecules.
目前已知，白细胞从血管内空间迁移至组织的基本生理过程依赖于一类现已被称为黏附分子的细胞表面分子。许多细胞间相互作用依赖于通过各种黏附分子，尤其是整合素进行的黏附及信号转导。阻断性和活化性单克隆抗体、基因敲除小鼠的研制，以及人类中罕见的“自然实验”（即存在某一种黏附分子缺失或功能障碍的个体），促进了对这些分子功能的研究。本综述描述了这些白细胞黏附缺陷，并讨论了它们如何为这些分子的功能提供了重要见解。
