Yamagishi M, Osakab N, Takizawa T, Osawa T
Functional Foods R&D Laboratories, Meiji Seika Kaisha, Ltd., Sakado, Saitama, Japan.
Lipids. 2001 Jan;36(1):67-71. doi: 10.1007/s11745-001-0669-9.
The effect of crude polyphenols (CLP) from cacao liquor on vitamin E-deficient rats was examined. The CLP fraction contained 49.8% antioxidative polyphenols such as catechins and their oligomers. Supplementation of the vitamin E-deficient diet with CLP for 7 wk did not prevent the decrease in alpha-tocopherol levels in the liver, kidney, heart, brain, and plasma. The lipid peroxide levels in these tissues increased in the group fed the vitamin E-deficient diet compared with the control group. However, these changes were inhibited in a dose-dependent manner as a result of supplementation of the vitamin E-deficient diet with 0.25, 0.5, or 1.0% CLP. The lipid peroxide levels in plasma increased in the group fed the vitamin E-deficient diet. This change tended to be suppressed as a result of supplementation of the diet with CLP, but the difference was not significant. There was no evidence of absorption and distribution of CLP to the tissues; however, CLP intake resulted in a decrease in oxidative stress without maintaining vitamin E levels in the plasma and the tissues.
研究了可可液粗多酚（CLP）对维生素E缺乏大鼠的影响。CLP组分含有49.8%的抗氧化多酚，如儿茶素及其低聚物。用CLP补充维生素E缺乏饮食7周并不能阻止肝脏、肾脏、心脏、大脑和血浆中α-生育酚水平的下降。与对照组相比，喂食维生素E缺乏饮食的组中这些组织的脂质过氧化物水平升高。然而，由于用0.25%、0.5%或1.0%的CLP补充维生素E缺乏饮食，这些变化以剂量依赖的方式受到抑制。喂食维生素E缺乏饮食的组中血浆脂质过氧化物水平升高。由于饮食中补充了CLP，这种变化有被抑制的趋势，但差异不显著。没有证据表明CLP被组织吸收和分布；然而，摄入CLP导致氧化应激降低，而没有维持血浆和组织中的维生素E水平。
