Morabito A, Bevilacqua P, Vitale S, Fanelli M, Gattuso D, Gasparini G
Division of Medical Oncology, Azienda Ospedaliera Bianchi-Melacrino Morelli, Reggio Calabria, Italy.
Tumori. 2000 Nov-Dec;86(6):472-4. doi: 10.1177/030089160008600608.
Apocrine carcinoma of the skin is a rare tumor. Wide surgical excision with complete removal of the neoplasm is the standard therapy and this appears to offer the best chance of cure. Radiotherapy may be used in case of local relapse or regional lymph node involvement. Systemic chemotherapy has not proved to be effective in the treatment of this tumor. We report on a 46-year-old woman with a recurrent apocrine carcinoma of the scalp that had previously been treated with surgery, radiotherapy and chemotherapy (Al-Saraff schedule). The patient was responsive to a second-line systemic chemotherapy regimen consisting of a weekly combination of methotrexate and bleomycin, and achieved long-term progression-free survival.
皮肤大汗腺癌是一种罕见的肿瘤。广泛手术切除并完整切除肿瘤是标准治疗方法，这似乎提供了最佳的治愈机会。局部复发或区域淋巴结受累时可使用放疗。全身化疗尚未证明对该肿瘤的治疗有效。我们报告了一名46岁女性，患有复发性头皮大汗腺癌，此前已接受手术、放疗和化疗（Al-Saraff方案）。该患者对由甲氨蝶呤和博来霉素每周联合组成的二线全身化疗方案有反应，并实现了长期无进展生存。
