Härmä R A, Suurkari S
Acta Otolaryngol. 1977 Jul-Aug;84(1-2):118-23. doi: 10.3109/00016487709123949.
During the last 12 years, 30 cases of tracheopathia chondro-osteoplastica have been diagnosed at the Department of Otolaryngology of Kuopio University. Ten of these were accidentally revealed by bronchoscopy, 2 by autopsy, but 18 were revealed through a systematic examination. Ten of these 18 were preliminarily diagnosed by indirect laryngoscopy. The average age for women was 51 and for men 42, the youngest patient being 11 and the oldest 71 years of age. The characteristic symptoms were long-term recurrent cough, hoarseness and periodic expectoration. The sputum was frequently abundant and crusty, and sometimes contained streaks of blood. Shortness of breath was a common symptom, but there were often entirely asymptomatic periods. The disease begins with a persistent purulent tracheitis, which, probably owing to calciphylaxis, causes accumulation of calcium salts in the tracheal mucosa. Cartilage and bone later develop around these accumulations. In most of the cases of tracheopathia chondro-osteoplastica in the present series, the condition was associated with atrophic rhinitis or pharyngitis. As the nasal disease improves, some regression may occur, though hardly healing. Calcium and phosphorus metabolism was not disturbed, and no immunological aberrations were found in any of the patients in this series.
在过去12年里，库奥皮奥大学耳鼻喉科诊断出30例气管软骨骨化症。其中10例是在支气管镜检查时偶然发现的，2例通过尸检发现，但18例是通过系统检查发现的。这18例中有10例最初是通过间接喉镜检查诊断出来的。女性的平均年龄为51岁，男性为42岁，最年轻的患者为11岁，最年长的为71岁。典型症状为长期反复咳嗽、声音嘶哑和周期性咳痰。痰液通常较多且呈结痂状，有时还带有血丝。气短是常见症状，但通常也有完全无症状的时期。该病始于持续性化脓性气管炎，可能由于钙盐沉着，导致气管黏膜中钙盐积聚。软骨和骨随后在这些沉积物周围形成。在本系列大多数气管软骨骨化症病例中，病情与萎缩性鼻炎或咽炎有关。随着鼻部疾病的改善，病情可能会有所缓解，尽管几乎无法治愈。钙和磷代谢未受干扰，本系列患者中未发现任何免疫异常。
