Sevincok L, Buyukozturk A, Dereboy F
Department of Psychiatry, Adnan Menderes University, Faculty of Medicine, Aydin, Turkey.
Can J Psychiatry. 2001 Feb;46(1):68-71. doi: 10.1177/070674370104600110.
To examine the lipid levels in a sample of patients with comorbid generalized anxiety disorder (GAD) and major depressive disorder (MDD).
Serum lipid concentrations were examined in 40 patients with both GAD and MDD, in 27 patients with MDD only, in 26 patients with GAD only, and in 24 healthy control subjects.
All mean serum cholesterol concentrations are presented in Table 1. The mean serum total cholesterol concentration in patients with both GAD and MDD was significantly higher than in MDD-only patients, GAD-only patients, and control subjects. The triglyceride concentration was also significantly higher in patients with both GAD and MDD than in MDD-only patients, GAD-only patients, and control subjects. Patients with both GAD and MDD had a lower mean high-density lipoprotein cholesterol (HDL-C) concentration than did patients with GAD only and control subjects. The serum concentration of low-density lipoprotein cholesterol (LDL-C) was higher in patients with both GAD and MDD than in patients with MDD only and GAD only and healthy control subjects.
Our findings indicate that the patients with both GAD and MDD have increased serum cholesterol, triglyceride, and LDL-C and reduced HDL-C levels. These patients may have a greater risk of mortality from coronary artery disease (CAD) than do patients with either depression or anxiety disorder.
研究共病广泛性焦虑障碍（GAD）和重度抑郁症（MDD）患者样本中的血脂水平。
检测了40例同时患有GAD和MDD的患者、27例仅患有MDD的患者、26例仅患有GAD的患者以及24名健康对照者的血清脂质浓度。
所有平均血清胆固醇浓度见表1。同时患有GAD和MDD的患者的平均血清总胆固醇浓度显著高于仅患有MDD的患者、仅患有GAD的患者以及对照者。同时患有GAD和MDD的患者的甘油三酯浓度也显著高于仅患有MDD的患者、仅患有GAD的患者以及对照者。同时患有GAD和MDD的患者的平均高密度脂蛋白胆固醇（HDL-C）浓度低于仅患有GAD的患者和对照者。同时患有GAD和MDD的患者的血清低密度脂蛋白胆固醇（LDL-C）浓度高于仅患有MDD的患者、仅患有GAD的患者以及健康对照者。
我们的研究结果表明，同时患有GAD和MDD的患者血清胆固醇、甘油三酯和LDL-C升高，HDL-C水平降低。这些患者死于冠状动脉疾病（CAD）的风险可能比患有抑郁症或焦虑症的患者更高。
