López-Peña M, Vázquez S, Alemañ N, López-Beceiro A, Muñoz F, Pereira J L, Nieto J M
Hospital Clínico Veterinario Rof Codina, Facultade de Veterinaria de Lugo, Universidade de Santiago de Compostela, E-27002 Lugo, Spain.
J Comp Pathol. 2001 Feb-Apr;124(2-3):207-11. doi: 10.1053/jcpa.2000.0432.
This report describes the histological and immunohistochemical findings in an adult male genet (Gennetta gennetta) which died a few hours after being found lying in a forest in Lugo (north-western Spain). Subpleural, yellowish, firm foci were found in the lung. Histopathological examination confirmed a diagnosis of endogenous lipid pneumonia. Microscopical lesions that gave rise to a suspicion of canine distemper virus (CDV) infection included lymphoid depletion, non-suppurative encephalitis and demyelination in the central nervous system, and the presence of inclusion bodies in renal tubules. Immunohistochemical examination was performed with the streptavidin-biotin-complex method and a monoclonal antibody against the nucleocapsid protein (NP) of CDV. Antigen was detected in epithelial, nervous and lymphoid cells in several organs. This would appear to be the first report of distemper-like infection in a genet.
本报告描述了一只成年雄性非洲林狸（Gennetta gennetta）的组织学和免疫组化结果。这只林狸在西班牙西北部卢戈的一片森林中被发现时已躺卧多时，数小时后死亡。在肺中发现了胸膜下淡黄色坚实病灶。组织病理学检查确诊为内源性脂质性肺炎。引起对犬瘟热病毒（CDV）感染怀疑的微观病变包括中枢神经系统的淋巴细胞耗竭、非化脓性脑炎和脱髓鞘，以及肾小管中存在包涵体。采用链霉亲和素-生物素复合物法和抗CDV核衣壳蛋白（NP）单克隆抗体进行免疫组化检查。在多个器官的上皮细胞、神经细胞和淋巴细胞中检测到抗原。这似乎是关于非洲林狸感染类似犬瘟热疾病的首例报告。
