John M S, Dimitrijevic A, Picton T W
Rotman Research Institute, Baycrest Centre for Geriatric Care, University of Toronto, 3560 Bathurst Street, Ontario, M6A 2E1, Toronto, Canada.
Clin Neurophysiol. 2001 Mar;112(3):555-62. doi: 10.1016/s1388-2457(01)00456-4.
To compare weighted averaging and artifact-rejection to normal averaging in the detection of steady-state responses.
Multiple steady-state responses were evoked by auditory stimuli modulated at rates between 78 and 95 Hz. The responses were evaluated after recording periods of 3, 6 and 10 min, using 5 averaging protocols: (1) normal averaging; (2) sample-weighted averaging; (3) noise-weighted averaging; (4) amplitude-based artifact-rejection; and (5) percentage-based artifact rejection. The responses were analyzed in the frequency domain and the signal-to-noise ratio was estimated by comparing the signals at the modulation-frequencies to the noise at adjacent frequencies.
Weighted averaging gave the best signal-to-noise ratios. Artifact-rejection was better than normal averaging but not as good as weighted averaging. Responses that were not significant with normal averaging became significant with weighted averaging much more frequently than vice versa. False alarm rates did not significantly differ among the protocols. The advantage of weighted averaging was especially evident when stimuli were presented at lower intensities or when smaller amounts (e.g. only 3 or 6 min) of data were evaluated. Weighted averaging was most effective when the background noise levels were variable. Weighted averaging underestimated the amplitude of the responses by about 2%.
Weighted averaging should be used instead of normal averaging for detecting steady-state responses.
比较加权平均法和伪迹剔除法与常规平均法在检测稳态反应中的效果。
采用78至95赫兹之间的调制频率的听觉刺激诱发多个稳态反应。在记录3、6和10分钟后,使用5种平均方案对反应进行评估:(1)常规平均法;(2)样本加权平均法;(3)噪声加权平均法;(4)基于幅度的伪迹剔除法;(5)基于百分比的伪迹剔除法。在频域中分析反应,并通过比较调制频率处的信号与相邻频率处的噪声来估计信噪比。
加权平均法给出了最佳的信噪比。伪迹剔除法比常规平均法更好,但不如加权平均法。常规平均法不显著的反应在加权平均法下更频繁地变得显著,反之则不然。各方案之间的误报率没有显著差异。当以较低强度呈现刺激或评估较少数据量(例如仅3或6分钟)时,加权平均法的优势尤为明显。当背景噪声水平可变时,加权平均法最为有效。加权平均法使反应幅度低估了约2%。
在检测稳态反应时,应使用加权平均法而非常规平均法。