Graff G R
Department of Child Health, University of Missouri-Columbia, 65212, USA.
Respiration. 2001;68(1):91-4. doi: 10.1159/000050470.
Major hemoptysis is a potentially life-threatening complication of cystic fibrosis (CF) lung disease. Bronchial artery embolization (BAE) along with treatment of a CF pulmonary exacerbation has become the most widely used therapeutic approach for major hemoptysis in CF. However, BAE has been associated with severe complications, especially when bronchial artery to spinal artery anastomoses are present. This case study describes the successful treatment of major hemoptysis in CF with tranexamic acid, in an individual in whom 12 previous BAE procedures had been performed and further procedures were contraindicated secondary to bronchial artery to spinal artery collaterals. Recurrence of the hemoptysis occurred after attempts had been made to withdraw the tranexamic acid. Tranexamic acid was resumed with resolution of the hemoptysis, and the therapy has been used continuously for 13 months without any complications.
大咯血是囊性纤维化（CF）肺部疾病潜在的危及生命的并发症。支气管动脉栓塞术（BAE）联合CF肺部急性加重期的治疗已成为CF大咯血最广泛使用的治疗方法。然而，BAE与严重并发症相关，尤其是当存在支气管动脉与脊髓动脉吻合时。本病例研究描述了一名曾接受过12次BAE手术且因支气管动脉与脊髓动脉侧支循环而禁忌进一步手术的个体，使用氨甲环酸成功治疗CF大咯血的情况。在尝试停用氨甲环酸后咯血复发。恢复使用氨甲环酸后咯血得到缓解，且该治疗已持续使用13个月，无任何并发症。
