Role of corticosteroids in stable chronic obstructive pulmonary disease.

Evidence supporting or refuting the use of corticosteroids in the treatment of patients with chronic obstructive pulmonary disease (COPD) has only recently become available, and evidence is still missing for a number of important clinical issues. Results from four large studies on the long-term effects of inhaled corticosteroids on COPD and other controlled studies on the more short-term effects of inhaled corticosteroids provide evidence that regular treatment with these drugs is only appropriate for a limited group of patients with COPD. These include symptomatic COPD patients with documented spirometric response to inhaled corticosteroids or those with a forced expiratory volume in 1 second (FEV(1)) less than 50% predicted and repeated exacerbations requiring treatments with antibiotics or oral corticosteroids.