Dinenno F A, Seals D R, DeSouza C A, Tanaka H
Human Cardiovascular Research Laboratory, Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA.
J Physiol. 2001 Mar 1;531(Pt 2):573-9. doi: 10.1111/j.1469-7793.2001.0573i.x.
Basal whole-limb blood flow is lower in older than in young healthy sedentary men due to a lower limb vascular conductance. In Study 1, we determined whether age-associated reductions in basal whole-leg (femoral artery) blood flow and vascular conductance are modulated by habitual physical activity by studying 89 healthy men aged 20-35 or 55-75 years (26 sedentary, 31 physically active and 32 endurance exercise trained). Femoral blood flow (duplex Doppler) and vascular conductance were approximately 20-30 % lower (P < 0.01) in the older men in all three physical activity groups. In Study 2, to determine the temporal pattern and relation to local metabolism and lean tissue mass of the age-associated reductions in femoral blood flow, we studied 142 healthy men aged 18-79 years. Femoral blood flow (r = -0.40) and vascular conductance (r = -0.51) were linearly and inversely related to age (both P < 0.001). Leg fat-free mass (r = -0.48) and estimated leg oxygen consumption (r = -0.49) declined with advancing age (both P < 0.001), and were strongly and positively related (r = 0.75; P < 0.001). The age-associated decline in femoral blood flow correlated with the corresponding reductions in leg fat-free mass and estimated leg oxygen consumption (both r = 0.47; P < 0.001). We concluded that: (1) basal whole-limb blood flow and vascular conductance decrease progressively with advancing age in healthy men; (2) reductions in both limb fat-free mass and oxygen consumption are related to the decline in whole-limb blood flow with age; and (3) habitual aerobic exercise does not appear to modulate the age-related reductions in basal limb blood flow and vascular conductance.
由于下肢血管传导性较低，健康久坐的老年男性的基础全肢血流量低于年轻男性。在研究1中，我们通过研究89名年龄在20 - 35岁或55 - 75岁的健康男性（26名久坐不动者、31名经常进行体育活动者和32名耐力训练者），来确定基础全腿（股动脉）血流量和血管传导性与年龄相关的降低是否受习惯性体育活动的调节。在所有三个体育活动组中，老年男性的股血流量（双功多普勒）和血管传导性均降低了约20 - 30%（P < 0.01）。在研究2中，为了确定与年龄相关的股血流量降低的时间模式及其与局部代谢和瘦组织质量的关系，我们研究了142名年龄在18 - 79岁的健康男性。股血流量（r = -0.40）和血管传导性（r = -0.51）与年龄呈线性负相关（均P < 0.001）。随着年龄的增长，腿部去脂体重（r = -0.48）和估计的腿部耗氧量（r = -0.49）下降（均P < 0.001）且两者呈强正相关（r = 0.75；P < 0.001）。与年龄相关的股血流量下降与腿部去脂体重和估计的腿部耗氧量的相应降低相关（均r = 0.47；P < 0.001）。我们得出结论：（1）在健康男性中，基础全肢血流量和血管传导性随年龄增长而逐渐降低；（2）肢体去脂体重和耗氧量的降低与全肢血流量随年龄的下降有关；（3）习惯性有氧运动似乎并未调节与年龄相关的基础肢体血流量和血管传导性的降低。
