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关节炎支原体诱导的小鼠慢性增殖性关节炎:体外对支原体抗原的细胞介导免疫反应的证明

Chronic proliferative arthritis of mice induced by Mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro.

作者信息

Cole B C, Golightly-Rowland L, Ward J R

出版信息

Infect Immun. 1975 May;11(5):1159-61. doi: 10.1128/iai.11.5.1159-1161.1975.

Abstract

Lymphocytes taken from mice chronically infected with Mycoplasma arthritidis exhibited a significant blastogenic response as measured by (3H)thymidine uptake when exposed in vitro to M. arthritidis antigens. The lymphocytes taken from 9 of 12 control mice of similar age exhibited an inhibition of (3H)thymidine uptake when exposed to M. arthritidis antigens.

摘要

从慢性感染关节炎支原体的小鼠体内获取的淋巴细胞,当在体外暴露于关节炎支原体抗原时,通过(3H)胸腺嘧啶核苷摄取量测定显示出显著的母细胞化反应。在12只年龄相似的对照小鼠中,有9只小鼠的淋巴细胞在暴露于关节炎支原体抗原时,(3H)胸腺嘧啶核苷摄取受到抑制。

相似文献

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Investigation into the origin of the antigens of Mycoplasma arthritidis cross-reacting with host tissue antigens.
FEMS Immunol Med Microbiol. 1995 Sep;12(1):9-15. doi: 10.1111/j.1574-695X.1995.tb00168.x.

本文引用的文献

1
Rheumatoid arthritis--an infection?类风湿性关节炎——一种感染性疾病?
Arthritis Rheum. 1963 Apr;6:159-65. doi: 10.1002/art.1780060207.

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