Cole B C, Aldridge K E, Ward J R
Infect Immun. 1977 Nov;18(2):393-9. doi: 10.1128/iai.18.2.393-399.1977.
Nonviable preparations of a wide variety of glucose-utilizing mycoplasma species, including Acholeplasma laidlawii and Spiroplasma citri, were found to be mitogenic for mouse lymphocytes. Particularly strong reactions were obtained with Mycoplasma synoviae, M. gallisepticum, M. pneumoniae, S. citri, and a strain of M. fermentans that was previously isolated from a leukemic patient. Nonviable preparations of arginine-utilizing mycoplasmas inhibited the uptake of [3H]thymidine by lymphocytes, but this effect could be reversed by heat treatment or arginine supplementation, and a stimulatory effect was then observed. Viable M. arthritidis was also found to have a mitogenic effect, as detected by an increased uptake of [3H]thymidine by normal lymphocytes and by autoradiographic techniques in which an increase in the numbers of transformed cells was seen. These observations provide the potential for enhanced immunological responsiveness or lymphokine-mediated inflammation in mycoplasma-infected hosts.
人们发现，包括莱氏无胆甾原体和柑橘螺原体在内的多种利用葡萄糖的支原体的无活性制剂，对小鼠淋巴细胞具有促有丝分裂作用。用滑膜支原体、鸡毒支原体、肺炎支原体、柑橘螺原体以及先前从一名白血病患者中分离出的发酵支原体菌株，可获得特别强烈的反应。利用精氨酸的支原体的无活性制剂会抑制淋巴细胞对[3H]胸腺嘧啶核苷的摄取，但这种作用可通过热处理或补充精氨酸来逆转，随后会观察到刺激作用。还发现活的关节炎支原体具有促有丝分裂作用，这可通过正常淋巴细胞对[3H]胸腺嘧啶核苷摄取的增加以及通过放射自显影技术检测到转化细胞数量的增加来证明。这些观察结果表明，支原体感染的宿主可能会增强免疫反应性或出现淋巴因子介导的炎症。
