Marsh B W, Bonfiglio M, Brady L P, Enneking W F
J Bone Joint Surg Am. 1975 Jan;57(1):1-9.
A study of twenty-five new cases of osteoblastoma and a review of 172 previously reported cases demonstrated the wide spectrum of manifestations of the lesion. The ratio of males to females was 2:1, with 80 per cent of the patients being under thirty years of age. The duration of complaints prior to diagnosis averaged seventeen months. The majority of the lesions were found in the spine or major long bones of the lower extremity. When complete excision of the tumor was done a cure always was the result, but incomplete curettage also affected a cure in some cases. Three cases presented in detail emphasize the wide variation in biological behavior which this lesion may exhibit. Histological characteristics of aneurysmal bone cyst may frequently appear in the tumor tissue. Radiotherapy does not alter the course of the disease and appears to be contraindicated.
一项对25例骨母细胞瘤新病例的研究以及对172例既往报道病例的回顾显示了该病变的广泛表现谱。男女比例为2:1，80%的患者年龄在30岁以下。诊断前的主诉持续时间平均为17个月。大多数病变位于脊柱或下肢主要长骨。当肿瘤完全切除时总能治愈，但在某些情况下，不完全刮除也能治愈。详细介绍的3例病例强调了该病变可能表现出的生物学行为的广泛差异。动脉瘤样骨囊肿的组织学特征可能经常出现在肿瘤组织中。放疗不会改变疾病进程，似乎是禁忌的。
