Coolidge F L, Thede L L, Jang K L
Department of Psychology, University of Colorado at Colorado Springs, 80933-7150, USA.
J Pers Disord. 2001 Feb;15(1):33-40. doi: 10.1521/pedi.15.1.33.18645.
The heritability of personality disorder features was investigated in 112 child (ages 4-15 years) twin pairs (70 monozygotic and 42 dizygotic pairs). Parents assessed personality disorder features using the Coolidge Personality and Neuropsychological Inventory for Children (CPNI; Coolidge, 1998) that measures 12 personality disorders according to the criteria in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (American Psychiatric Association, 1994). Structural equation model-fitting methods indicated that the median heritability coefficient for the 12 scales was .75 (ranging from .81 for the Dependent and Schizotypal Personality Disorder scales to .50 for the Paranoid and Passive-Aggressive Personality Disorder scales). These results suggest that childhood personality disorders have a substantial genetic component and that they are similar to heritability estimates of personality disorder traits in adults and counter hypotheses that only temperaments and higher-order personality disorder traits have significant genetic components (Paris, 1997).
在112对儿童（4至15岁）双胞胎（70对同卵双胞胎和42对异卵双胞胎）中研究了人格障碍特征的遗传力。父母使用《柯立芝儿童人格与神经心理量表》（CPNI；柯立芝，1998年）评估人格障碍特征，该量表根据《精神障碍诊断与统计手册》（DSM-IV）（美国精神病学协会，1994年）的标准测量12种人格障碍。结构方程模型拟合方法表明，12个量表的遗传力系数中位数为0.75（范围从依赖型和分裂型人格障碍量表的0.81到偏执型和被动攻击型人格障碍量表的0.50）。这些结果表明，儿童期人格障碍有很大的遗传成分，并且它们与成人期人格障碍特征的遗传力估计相似，这反驳了只有气质和高阶人格障碍特征才有显著遗传成分的假设（帕里斯，1997年）。
