Tkachuk A N, Moormann A M, Poore J A, Rochford R A, Chensue S W, Mwapasa V, Meshnick S R
Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.
J Infect Dis. 2001 Mar 15;183(6):967-72. doi: 10.1086/319248. Epub 2001 Feb 9.
Malaria and human immunodeficiency virus (HIV) coinfections are common in pregnant women in sub-Saharan Africa. The current study shows that placentas of malaria-infected women contain 3 times as much CC chemokine receptor 5 (CCR5) RNA as placentas of women without malaria. By immunohistochemistry, CCR5(+) maternal macrophages were seen in placentas from malaria-infected women but not in placentas from malaria-uninfected women. In addition, CCR5 also was found on fetal Hofbauer cells in placentas from both groups. Thus, malaria infections increase the potential reservoir for HIV in the placenta by increasing the number of HIV target cells.
疟疾与人类免疫缺陷病毒（HIV）合并感染在撒哈拉以南非洲的孕妇中很常见。当前研究表明，感染疟疾的女性胎盘所含的CC趋化因子受体5（CCR5）RNA是未感染疟疾女性胎盘的3倍。通过免疫组织化学方法，在感染疟疾女性的胎盘中可见CCR5（+）母体巨噬细胞，而未感染疟疾女性的胎盘中则未见。此外，在两组胎盘的胎儿霍夫鲍尔细胞上也发现了CCR5。因此，疟疾感染通过增加HIV靶细胞数量，增加了胎盘内HIV的潜在储存库。
