Jaworowski Anthony, Kamwendo Deborah D, Ellery Philip, Sonza Secondo, Mwapasa Victor, Tadesse Eyob, Molyneux Malcolm E, Rogerson Stephen J, Meshnick Steven R, Crowe Suzanne M
Macfarlane Burnet Institute for Medical Research and Public Health, Melbourne, Victoria, Australia.
J Infect Dis. 2007 Jul 1;196(1):38-42. doi: 10.1086/518443. Epub 2007 May 16.
In a cross-sectional study, monocyte subsets in placental, cord, and maternal peripheral blood from pregnant Malawian women with human immunodeficiency virus (HIV)-1 infection and/or malaria were analyzed. HIV-uninfected Malawian women had higher baseline proportions of CD16(+) monocytes than those reported for healthy adults in developed countries. Malaria was associated with an increase in the proportion of CD16(+) monocytes that was significant in women coinfected with HIV-1. CD16(+) monocytes expressed higher CCR5 levels than did CD14(hi)/CD16(-) monocytes and were significantly more likely to harbor HIV-1. These data suggest a role for CD16(+) monocytes in the pathogenesis of maternal malaria and HIV-1 infections.
在一项横断面研究中，对感染人类免疫缺陷病毒（HIV）-1和/或疟疾的马拉维孕妇的胎盘、脐带血和母体外周血中的单核细胞亚群进行了分析。未感染HIV的马拉维妇女的CD16(+)单核细胞基线比例高于发达国家健康成年人的报告比例。疟疾与CD16(+)单核细胞比例增加有关，这在合并感染HIV-1的女性中具有显著性。CD16(+)单核细胞表达的CCR5水平高于CD14(hi)/CD16(-)单核细胞，并且携带HIV-1的可能性显著更高。这些数据表明CD16(+)单核细胞在母体疟疾和HIV-1感染的发病机制中发挥作用。
