Falsey A R, Walsh E E, Francis C W, Looney R J, Kolassa J E, Hall W J, Abraham G N
Department of Medicine, Rochester General Hospital, and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14621, USA.
J Infect Dis. 2001 Apr 1;183(7):995-9. doi: 10.1086/319275. Epub 2001 Feb 23.
Influenza epidemics are associated with significant morbidity and mortality in the elderly, with a substantial proportion of deaths due to cardiovascular events. Elevations of acute-phase proteins have been associated with an increased risk of atherosclerotic events. Therefore, serum amyloid A (SAA) and C-reactive protein (CRP) were measured during influenza illness and 4 weeks later in 7 young persons, 15 elderly outpatients, and 36 hospitalized adults. Striking elevations were seen in mean acute SAA and CRP levels in all groups, but hospitalized patients had the highest levels (SAA, 503 vs. 310 microg/mL [P=.006]; CRP, 120 vs. 34 microg/mL [P<.001]). The presence of dyspnea, wheezing, and fever was also associated with high CRP levels. Influenza infection is associated with significant elevations of SAA and CRP levels in elderly patients, especially those who require hospitalization. It is possible that direct effects of CRP may exacerbate preexisting atherosclerotic lesions and may help explain cardiovascular events associated with acute influenza.
流感流行与老年人的高发病率和死亡率相关，相当一部分死亡是由心血管事件导致的。急性期蛋白升高与动脉粥样硬化事件风险增加有关。因此，在流感患病期间及4周后，对7名年轻人、15名老年门诊患者和36名住院成人测量了血清淀粉样蛋白A（SAA）和C反应蛋白（CRP）。所有组的平均急性SAA和CRP水平均显著升高，但住院患者的水平最高（SAA，503对310微克/毫升[P = 0.006]；CRP，120对34微克/毫升[P < 0.001]）。呼吸困难、喘息和发热的出现也与高CRP水平相关。流感感染与老年患者，尤其是需要住院治疗的患者的SAA和CRP水平显著升高有关。CRP的直接作用可能会加剧已有的动脉粥样硬化病变，并可能有助于解释与急性流感相关的心血管事件。
