Carty Cara L, Heagerty Patrick, Nakayama Karen, McClung E Clair, Lewis Julieann, Lum Dawn, Boespflug Erin, McCloud-Gehring Carrie, Soleimani Behrooz R, Ranchalis Jane, Bacus Tamara J, Furlong Clement E, Jarvik Gail P
University of Washington, Department of Epidemiology, Seattle, Wash, USA.
Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2738-44. doi: 10.1161/01.ATV.0000248534.30057.b5. Epub 2006 Oct 5.
Inflammatory markers are associated with vascular disease; however, variation in the acute phase response (APR) has not been evaluated. We evaluated whether the APR magnitude in men with severe carotid artery disease (CAAD) (>80% stenosis) differed from that of men without stenosis (<15% stenosis).
White males with (n=43) and without (n=61) severe CAAD receiving clinical influenza vaccinations were recruited. Their baseline and 24-hour after -vaccination blood samples were assayed for C-reactive protein (CRP), IL-6, and serum amyloid-a (SAA). In vivo APR to vaccination was measurable and varied among subjects. Adjusted for age, smoking, oral hypoglycemics, aspirin, and stain use, the relative 24-hour changes in levels of ln(CRP), ln(IL-6), and ln(SAA) were higher in men with CAAD than in men without, but only the SAA response was significant (P=0.02); the relative SAA response was 1.6 (95% confidence interval, 1.1 to 2.5) times higher in men with than without CAAD. The APR for all markers appeared to be independent of baseline levels.
Influenza vaccination results in a mild, but measurable, APR in men with and without CAAD. SAA APR variability may be a predictor of severe vascular disease that is independent of basal SAA level.
炎症标志物与血管疾病相关；然而，急性期反应（APR）的变异性尚未得到评估。我们评估了患有严重颈动脉疾病（CAAD）（狭窄>80%）的男性与无狭窄（狭窄<15%）的男性的APR幅度是否存在差异。
招募了患有（n = 43）和未患有（n = 61）严重CAAD且接受临床流感疫苗接种的白人男性。对他们接种疫苗前的基线血样和接种后24小时的血样进行C反应蛋白（CRP）、白细胞介素-6（IL-6）和血清淀粉样蛋白A（SAA）检测。接种疫苗后的体内APR是可测量的，且在受试者之间存在差异。在对年龄、吸烟、口服降糖药、阿司匹林和他汀类药物使用情况进行校正后，患有CAAD的男性ln(CRP)、ln(IL-6)和ln(SAA)水平的相对24小时变化高于未患CAAD的男性，但只有SAA反应具有统计学意义（P = 0.02）；患有CAAD的男性的相对SAA反应比未患CAAD的男性高1.6倍（95%置信区间，1.1至2.5）。所有标志物的APR似乎都与基线水平无关。
流感疫苗接种在患有和未患有CAAD的男性中均会导致轻微但可测量的APR。SAA的APR变异性可能是严重血管疾病的一个预测指标，且独立于基础SAA水平。
