Yoneyama Y, Suzuki S, Sawa R, Kiyokawa Y, Power G G, Araki T
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Obstet Gynecol. 2001 Mar;97(3):366-70. doi: 10.1016/s0029-7844(00)01184-4.
To measure the correlation of plasma adenosine levels with platelet activation in women with preeclampsia.
Plasma adenosine concentration and expression of P-selectin, a marker for platelet activation, were measured in 18 normal pregnant women and 18 preeclamptic women. The effect of 8-sulfophenyltheophylline, an adenosine receptor blocker, on expression of P-selectin on platelets also was measured.
Plasma adenosine level averaged 0.77 +/- 0.11 microM (standard error of the mean [SEM]) in women with preeclampsia, significantly higher than the mean level of 0.47 +/- 0.08 microM in women with normal pregnancies (P <.05). Expression of P-selectin on platelets averaged 7.8 +/- 1.2% in women with preeclampsia, also significantly higher than the mean level of 4.7 +/- 0.7% in normal pregnancy (P <.05). Adenosine receptor blockade significantly increased expression of P-selectin on platelets in women with preeclampsia by 26% (P <.05), which was significantly higher than the 13% increase of activation in those with normal pregnancies (P <.05).
Adenosine is an established platelet activation suppressor. Increased plasma levels of adenosine in preeclampsia might partially compensate and tend to prevent further excessive platelet activation in women with preeclampsia.
测定子痫前期女性血浆腺苷水平与血小板活化之间的相关性。
检测18例正常孕妇和18例子痫前期孕妇的血浆腺苷浓度以及血小板活化标志物P-选择素的表达。还测定了腺苷受体阻滞剂8-磺基苯基茶碱对血小板上P-选择素表达的影响。
子痫前期女性的血浆腺苷水平平均为0.77±0.11微摩尔/升（均值标准误[SEM]），显著高于正常妊娠女性的平均水平0.47±0.08微摩尔/升（P<0.05）。子痫前期女性血小板上P-选择素的表达平均为7.8±1.2%，也显著高于正常妊娠时的平均水平4.7±0.7%（P<0.05）。腺苷受体阻断使子痫前期女性血小板上P-选择素的表达显著增加26%（P<0.05），这显著高于正常妊娠女性活化增加的13%（P<0.05）。
腺苷是一种公认的血小板活化抑制剂。子痫前期患者血浆腺苷水平升高可能部分起到代偿作用，并倾向于防止子痫前期女性血小板进一步过度活化。
