Selroos O B
Crit Rev Clin Lab Sci. 1986;24(3):185-216. doi: 10.3109/10408368609110273.
The clinical course of sarcoidosis is varying and unpredictable. Once the diagnosis has been made, the clinician needs simple tests to detect and predict remission or progression, to determine whether treatment is effective or not, and to assess the clinical activity of the disease. Sarcoidosis is a multisystem disease, but the lungs are almost always involved. Traditionally, the clinical management has therefore included chest X-rays and lung function studies. Extrapulmonary lesions have been followed in different ways. Sensitive and reproducible biochemical tests would be helpful in evaluating the clinical course of patients with sarcoidosis, if they measure functions related to the granulomatous inflammation. This review will deal with measurements of serum and urinary calcium, and 1,25-dihydroxyvitamin D. The usefulness of single and serial determinations of lysozyme, angiotensin converting enzyme, beta 2-microglobulin, collagenase, carboxypeptidase and glucuronidase in serum, bronchoalveolar lavage fluid, and other biological fluids will be discussed.
结节病的临床病程多变且难以预测。一旦确诊，临床医生需要简单的检查来检测和预测缓解或进展情况，确定治疗是否有效，并评估疾病的临床活动度。结节病是一种多系统疾病，但肺部几乎总是受累。因此，传统的临床管理包括胸部X光检查和肺功能研究。肺外病变的监测方式各不相同。如果能测量与肉芽肿性炎症相关的功能，敏感且可重复的生化检查将有助于评估结节病患者的临床病程。本综述将探讨血清和尿钙以及1,25 - 二羟维生素D的检测。还将讨论血清、支气管肺泡灌洗液和其他生物体液中溶菌酶、血管紧张素转换酶、β2 - 微球蛋白、胶原酶、羧肽酶和葡萄糖醛酸酶单次及系列测定的实用性。
