Giannoudis A, Herrington C S
Department of Pathology, Royal Liverpool University Hospital, Duncan Building, Daulby Street, Liverpool L69 3GA, UK.
J Pathol. 2001 Mar;193(3):295-302. doi: 10.1002/1096-9896(2000)9999:9999<::AID-PATH809>3.0.CO;2-C.
Human papillomaviruses (HPVs) play a central role in the aetiology of cervical neoplasia. However, only a small proportion of cervical intraepithelial lesions infected with high-risk HPVs will progress to invasive cervical carcinoma, which indicates the involvement of additional factors. An important emerging viral factor is naturally occurring intratypic sequence variation. Such variation has been used to study the geographical spread of HPVs, but there is increasing evidence that it may be important in determining the risk of development of neoplastic disease. The collected data indicate that different HPV variants have altered biochemical and biological properties and represent an additional risk factor in the development of squamous intraepithelial lesions and invasive carcinoma of the cervix. This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice.
人乳头瘤病毒（HPV）在宫颈肿瘤的病因学中起着核心作用。然而，仅有一小部分感染高危HPV的宫颈上皮内病变会发展为浸润性宫颈癌，这表明还涉及其他因素。一个重要的新出现的病毒因素是自然发生的型内序列变异。这种变异已被用于研究HPV的地理传播，但越来越多的证据表明，它在确定肿瘤性疾病的发生风险方面可能很重要。收集的数据表明，不同的HPV变异体具有改变的生化和生物学特性，是宫颈鳞状上皮内病变和浸润性癌发生发展中的一个额外风险因素。这不仅可能与HPV感染的生物学及其与鳞状肿瘤的关联有关，还可能与临床实践中HPV分型的应用有关。
