五肽胃泌素与镁对人体胃酸分泌的联合作用。
The combined effect of pentagastrin and magnesium on gastric acid secretion in man.
作者信息
Christiansen J
出版信息
Scand J Gastroenterol. 1975;10(2):203-5.
The mechanism by which magnesium acts on gastric acid secretion is obscure. It has been demonstrated that magnesium inhibits basal as well as hypercalcemic-induced acid secretion. It has furthermore been shown that magnesium does not interfere with gastrin release. It is not, however, known if magnesium acts as an antagonist to gastrin. To elucidate this the combined effect of pentagastrin (0.5 mug/kg-hr) and magnesium sulphate (0.4 meq Mg++/kg-hr) was studied in 10 healthy subjects. The secretory plateau obtained during pentagastrin infusion was unchanged during the combined infusion of pentagastrin and magnesium. This applies to volume secretion, acidity as well as acid output.
镁作用于胃酸分泌的机制尚不清楚。已经证明，镁可抑制基础胃酸分泌以及高钙血症诱导的胃酸分泌。此外还表明，镁不会干扰胃泌素的释放。然而，镁是否作为胃泌素的拮抗剂起作用尚不清楚。为了阐明这一点，在10名健康受试者中研究了五肽胃泌素（0.5微克/千克·小时）和硫酸镁（0.4毫当量镁离子/千克·小时）的联合作用。在五肽胃泌素输注期间获得的分泌平台在五肽胃泌素和镁联合输注期间没有变化。这适用于分泌量、酸度以及酸排出量。
Zotero 插件