Hagiwara K, Yamanaka H, Hisaeda K, Taharaguchi S, Kirisawa R, Iwai H
School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan.
Vet Res Commun. 2001 Feb;25(2):99-108. doi: 10.1023/a:1006400801305.
Inflammatory cytokines, such as interleukin (IL)-6, have been shown to reflect clinical signs in certain conditions in diseased animals. In this study, we quantified the IL-6 concentrations in the serum and milk whey from 94 dairy cows with acute clinical mastitis and 55 healthy lactating cows. The IL-6 concentrations in serum from mastitic cows were significantly higher on the first day of illness compared to those of normal cows. Higher concentrations of IL-6 were also detected in the whey from mastitic cows, whereas low concentrations of IL-6 were detected in both serum and whey samples from normal cows. IL-6 concentrations in the serum taken at the onset of illness from cows that later required euthanasia were significantly higher than those in samples from cows that later recovered. These results suggest that serum IL-6 concentrations may be of prognostic value in identifying cows with severe mastitis.
炎症细胞因子，如白细胞介素（IL）-6，已被证明在患病动物的某些情况下能反映临床症状。在本研究中，我们对94头患有急性临床乳腺炎的奶牛和55头健康泌乳奶牛的血清和乳清中的IL-6浓度进行了定量分析。与正常奶牛相比，患乳腺炎奶牛血清中的IL-6浓度在发病第一天显著更高。在患乳腺炎奶牛的乳清中也检测到较高浓度的IL-6，而在正常奶牛的血清和乳清样本中均检测到低浓度的IL-6。后来需要实施安乐死的奶牛在发病初期采集的血清中的IL-6浓度显著高于后来康复奶牛样本中的浓度。这些结果表明，血清IL-6浓度在识别患有严重乳腺炎的奶牛方面可能具有预后价值。
