Grime P R, Ris L, Binns C, Carruthers J R, Williams S
Department of Occupational Health & Safety, King's College Hospital, Denmark Hill, London, SE5 9RS, UK.
J Infect. 2001 Jan;42(1):27-32. doi: 10.1053/jinf.2000.0765.
To review the management of occupational exposure to definite or suspected HIV-infected blood, following the introduction of the 1997 UK Department of Health guidelines on the use of post-exposure prophylaxis.
Cross-sectional telephone survey of protocols in 71 NHS Trusts in the Pan-Thames region. Retrospective postal survey of the management of each definite or suspected HIV blood exposure between 1 July 1997 and 30 June 1999.
Sixty-two (93%) Trusts had a written protocol, with many specialties involved in exposure management. Twenty-four Trusts reported 171 occupational exposures to definite or suspected HIV-infected blood. Of 97 definite HIV exposures, eight (8%) were discovered on post-incident HIV testing of the source patient; to which most source patients agreed when approached. Seventy-two (74%) exposed health care workers started prophylaxis and 49 (68%) completed the recommended 4-week course. Only half of those whose exposures occurred more than 6 months ago were known to have had a follow-up HIV test.
Although most Trusts have implemented the Department of Health's guidance, collecting data on individual exposures proved difficult. We suggest that a designated department in each Trust co-ordinates and records HIV exposure management. Routine HIV testing is acceptable to most source patients and is appropriate in areas with a high prevalence of HIV seropositivity.
在1997年英国卫生部关于暴露后预防用药指南出台后,回顾对明确或疑似感染艾滋病毒血液的职业暴露管理情况。
对泛泰晤士地区71家国民健康服务信托机构的方案进行横断面电话调查。对1997年7月1日至1999年6月30日期间每例明确或疑似艾滋病毒血液暴露的管理情况进行回顾性邮寄调查。
62家(93%)信托机构有书面方案,许多专业参与暴露管理。24家信托机构报告了171例明确或疑似感染艾滋病毒血液的职业暴露。在97例明确的艾滋病毒暴露中,8例(8%)是在对源患者进行事后艾滋病毒检测时发现的;大多数源患者在被询问时表示同意。72名(74%)暴露的医护人员开始预防用药,49名(68%)完成了推荐的4周疗程。只有一半暴露发生超过6个月的人员已知进行了后续艾滋病毒检测。
尽管大多数信托机构已实施卫生部的指导意见,但收集个体暴露数据证明很困难。我们建议每个信托机构指定一个部门来协调和记录艾滋病毒暴露管理情况。大多数源患者接受常规艾滋病毒检测,在艾滋病毒血清阳性率高的地区进行常规检测是合适的。