酿酒酵母减数分裂过程中纺锤极的保守性复制。
Conservative duplication of spindle poles during meiosis in Saccharomyces cerevisiae.
作者信息
Wesp A, Prinz S, Fink G R
机构信息
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.
出版信息
J Bacteriol. 2001 Apr;183(7):2372-5. doi: 10.1128/JB.183.7.2372-2375.2001.
Abstract
During sporulation in diploid Saccharomyces cerevisiae, spindle pole bodies acquire the so-called meiotic plaque, a prerequisite for spore formation. Mpc70p is a component of the meiotic plaque and is thus essential for spore formation. We show here that MPC70/mpc70 heterozygous strains most often produce two spores instead of four and that these spores are always nonsisters. In wild-type strains, Mpc70p localizes to all four spindle pole bodies, whereas in MPC70/mpc70 strains Mpc70p localizes to only two of the four spindle pole bodies, and these are always nonsisters. Our data can be explained by conservative spindle pole body distribution in which the two newly synthesized meiosis II spindle pole bodies of MPC70/mpc70 strains lack Mpc70p.
摘要
在二倍体酿酒酵母的孢子形成过程中，纺锤体极体获得所谓的减数分裂斑块，这是孢子形成的先决条件。Mpc70p是减数分裂斑块的一个组成部分，因此对孢子形成至关重要。我们在此表明，MPC70/mpc70杂合菌株最常产生两个而非四个孢子，并且这些孢子总是非姐妹孢子。在野生型菌株中，Mpc70p定位于所有四个纺锤体极体，而在MPC70/mpc70菌株中，Mpc70p仅定位于四个纺锤体极体中的两个，且这两个总是非姐妹纺锤体极体。我们的数据可以通过保守的纺锤体极体分布来解释，即MPC70/mpc70菌株新合成的两个减数分裂II纺锤体极体缺乏Mpc70p。
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