Davydov D R
Laboratory of Microsomal Oxidation, The Institute of Biomedical Chemistry of Russian Academy of Medical Sciences, 10 Pogodinskaya ul., Moscow, Russia 119992.
Trends Biochem Sci. 2001 Mar;26(3):155-60. doi: 10.1016/s0968-0004(00)01749-7.
The main function of eukaryotic microsomal monooxygenase (MMO) is thought to be the oxygenation of xenobiotics and hydrophobic endogenous substrates. However, there are important inconsistencies in the concept that the biological role of MMO is limited to the catalysis of these reactions. It is probable that MMO is also a regulated generator of reactive oxygen species (ROS) that is involved in both the initiation and execution of apoptosis. Additional support for this hypothesis came with the discovery of a role for cytochrome c (cyt c) in apoptotic signaling. This article introduces the theory that microsomal cytochrome b(5), which modulates the production of ROS in MMO, is among the principal interacting targets of cyt c. The role of this interaction in the initiation of apoptosis is discussed.
真核微粒体单加氧酶（MMO）的主要功能被认为是对外源化合物和疏水性内源性底物进行氧化。然而，认为MMO的生物学作用仅限于催化这些反应的观点存在重要的矛盾之处。MMO很可能还是活性氧（ROS）的调节生成器，参与细胞凋亡的起始和执行过程。细胞色素c（cyt c）在凋亡信号传导中的作用的发现为这一假说提供了更多支持。本文介绍了一种理论，即微粒体细胞色素b5（cyt b5）可调节MMO中ROS的产生，它是cyt c的主要相互作用靶点之一。文中还讨论了这种相互作用在细胞凋亡起始过程中的作用。
