Andersen L, Fejerskov O, Theilade J
Acta Pathol Microbiol Scand A. 1975 Jan;83(1):69-76. doi: 10.1111/j.1699-0463.1975.tb01358.x.
Eight peripheral and 2 central oral giant cell granulomas have been studied in the electron microscope in order to examine the structure and nature of the vessels. The vascular wall was composed of a continous layer of endothelial cells resting on a basal lamina, which was frequently multilayered. The lamina also surrounded scattered subjacent pericytes. The endothelial cells overlapped slightly so as to form narrow intercellular spaces. Based on these observations the vessels are supposed to be postcapillary venules. Dark cells exhibiting degenerative features were encountered in the endothelial lining of most vessels. Small gaps and larger defects in the vascular lining allowed direct continuity between the lumen and the perivascular tissue. It is suggested that the extreme extravasation of red blood cells frequently observed in oral giant cell granulomas may be mediated through this incomplete lining.
为了研究血管的结构和性质，我们对8例外周型和2例中央型口腔巨细胞肉芽肿进行了电子显微镜观察。血管壁由一层连续的内皮细胞组成，内皮细胞位于基膜上，基膜常为多层。基膜也包绕着散在的周细胞。内皮细胞稍有重叠，形成狭窄的细胞间隙。基于这些观察结果，推测这些血管为毛细血管后微静脉。在大多数血管的内皮衬里中发现了具有退行性特征的暗细胞。血管衬里的小间隙和较大缺损使得管腔与血管周围组织直接相通。提示口腔巨细胞肉芽肿中常见的红细胞大量外渗可能是通过这种不完整的衬里介导的。
