Balázs M, Dénes J, Lukács V F
Virchows Arch A Pathol Anat Histol. 1978 Aug 22;379(2):157-68. doi: 10.1007/BF00432485.
This paper discusses the fine structure of multiple haemangioendothelioma of the liver. There have been no previous reports of electron microscopic studies of this tumour, which was found to be composed of young capillaries continuous in type and varying in calibre. The capillaries were lined by actively proliferating, immature endothelial cells with pericytes forming an integral part of the tumour. Their morphological characteristics indicated intensive protein production. The authors suggest that the active pericytes play a role in the production of reticular fibres of the tumour. Following corticosteroid therapy, regression of tumour nodules occurred in this case in the interval between surgery and autopsy. This was confirmed by histological studies. The results seem to support the hypothesis that actively proliferating, young endothelial cells show an increased sensitivity to corticosteroids.
本文讨论了肝脏多发性血管内皮瘤的精细结构。此前尚无关于该肿瘤的电子显微镜研究报告，发现该肿瘤由类型连续、管径各异的年轻毛细血管组成。毛细血管内衬有活跃增殖的未成熟内皮细胞，周细胞是肿瘤的一个组成部分。它们的形态特征表明有大量蛋白质产生。作者认为活跃的周细胞在肿瘤网状纤维的产生中起作用。在该病例中，皮质类固醇治疗后，在手术和尸检之间的间隔期肿瘤结节出现消退。组织学研究证实了这一点。结果似乎支持这样的假说，即活跃增殖的年轻内皮细胞对皮质类固醇更为敏感。
