Günhan M, Günhan O, Celasun B, Mutlu M, Bostanci H
Department of Periodontalogy, Ankara University, School of Dentistry, Beşevler, Turkey.
J Oral Sci. 1998 Jun;40(2):57-60. doi: 10.2334/josnusd.40.57.
Peripheral giant cell granulomas are common proliferative lesions of the oral cavity with a predilection for females. In this study, the presence of estrogen and progesterone receptors in 26 peripheral giant cell granuloma cases were studied utilizing the immunoperoxidase technique. In fourteen cases, estrogen receptor positivity was found in stromal cells. In ten of these, osteoclast-type giant cells also exhibited estrogen receptor immunostaining. Progesterone receptor expression was not detected. It was concluded that the cells forming peripheral giant cell granuloma are potential targets for estrogens and that these lesions might be conditioned by sex hormones.
外周巨细胞肉芽肿是口腔常见的增殖性病变，好发于女性。在本研究中，采用免疫过氧化物酶技术对26例外周巨细胞肉芽肿病例中的雌激素和孕激素受体进行了研究。在14例病例中，基质细胞中发现雌激素受体阳性。其中10例，破骨细胞型巨细胞也表现出雌激素受体免疫染色。未检测到孕激素受体表达。得出的结论是，形成外周巨细胞肉芽肿的细胞是雌激素的潜在靶点，并且这些病变可能受性激素影响。
