Radhakrishnan A, Li X M, Brown R E, McConnell H M
Department of Chemistry, Stanford University, CA 94305, USA.
Biochim Biophys Acta. 2001 Mar 9;1511(1):1-6. doi: 10.1016/s0005-2736(01)00274-7.
Some binary mixtures of cholesterol and phospholipids in monolayers have thermodynamic phase diagrams with two upper miscibility critical points. This feature has been interpreted in terms of 'condensed complexes' between the phospholipid and cholesterol. The present work gives evidence for the formation of complexes with a common simple integral stoichiometry in binary mixtures of cholesterol and a series of five sphingomyelins where the amide-linked acyl chain length is varied. This indicates that these complexes have a distinct geometry even though they form a liquid phase.
胆固醇与磷脂在单分子层中的一些二元混合物具有包含两个上临界互溶点的热力学相图。这一特性已根据磷脂与胆固醇之间的“凝聚复合物”进行了解释。目前的研究为胆固醇与一系列五种神经鞘磷脂的二元混合物中形成具有共同简单整数化学计量比的复合物提供了证据，其中酰胺连接的酰基链长度有所不同。这表明这些复合物即使形成液相也具有独特的几何结构。
