Fagien S, Elson M L
Clin Plast Surg. 2001 Jan;28(1):63-81.
Soft-tissue augmentation lends another dimension to facial rejuvenation. Human collagen tissue matrix offers the most physiologic solution to dermal volume depletion, structural soft-tissue malposition, and the correction of facial rhytides and various soft-tissue contour defects. Results with the use of Dermalogen have been comparable with other injectable dermal agents with the most natural effects. The absolute longevity or persistence of human tissue collagen matrix has not been established fully and depends on facial region, technique, and total volume administered. The natural fate of most related bio-materials suggest that internal dosing is required to maintain maximum effects. Dermaplant is now commercially available and is an effective agent for facial soft-tissue augmentation-nasolabial folds and lip augmentation-and secondary eyelid and nasal reconstruction. Final clinical studies will provide data on long-term persistence and relative results when compared with other acellular dermal and alloplastic grafts.
软组织填充为面部年轻化增添了新的维度。人胶原蛋白组织基质为真皮容量减少、结构性软组织错位以及面部皱纹和各种软组织轮廓缺陷的矫正提供了最符合生理的解决方案。使用真皮素的效果与其他具有最自然效果的可注射真皮制剂相当。人体组织胶原蛋白基质的绝对寿命或持久性尚未完全确定，这取决于面部区域、技术和给药总量。大多数相关生物材料的自然命运表明，需要进行内部给药以维持最大效果。Dermaplant现已上市，是一种用于面部软组织填充（鼻唇沟和唇部填充）以及二期眼睑和鼻重建的有效制剂。最终的临床研究将提供与其他脱细胞真皮和异体植入物相比的长期持久性和相对效果的数据。
