Goligorsky M S
Department of Medicine, State University of New York, Stony Brook, New York 11794-8152, USA.
Am J Physiol Renal Physiol. 2001 Apr;280(4):F551-61. doi: 10.1152/ajprenal.2001.280.4.F551.
As animals respond to environmental stress with a set of default reactions described as the "fight-or-flight" response, so do epithelial and endothelial cells when they are confronting stressors in their microenvironment. This review will summarize a growing body of data suggesting the existence of a set of stereotypical cellular reactions to stress, provide some examples of diseases that are characterized by excessive flight reactions, describe the cellular mechanisms whereby the fight-or-flight reaction is accomplished, as well as cellular mechanisms triggering either fight or flight. It is proposed that cell-matrix adhesion is a sensitive indicator of the severity of stress. This indicator is interfaced with several default programs for cellular survival or death, thus dictating the fate of the cell. Some diagnostic and therapeutic applications of the concept, presently used and potentially useful, are outlined. The essential feature of this concept is its ability to categorize cellular events in terms of either type of default reaction, predict the details of each, and potentially exploit them clinically.
动物会通过一系列被称为“战斗或逃跑”反应的默认反应来应对环境压力，上皮细胞和内皮细胞在面对其微环境中的应激源时也是如此。本综述将总结越来越多的数据，这些数据表明存在一组对压力的刻板细胞反应，提供一些以过度逃跑反应为特征的疾病实例，描述战斗或逃跑反应得以实现的细胞机制，以及触发战斗或逃跑的细胞机制。有人提出，细胞与基质的粘附是压力严重程度的敏感指标。该指标与几个细胞存活或死亡的默认程序相联系，从而决定细胞的命运。概述了该概念目前已使用的以及潜在有用的一些诊断和治疗应用。这一概念的基本特征是它能够根据默认反应的类型对细胞事件进行分类，预测每种反应的细节，并有可能在临床上加以利用。
