内毒素给予健康人后细胞相关趋化因子的诱导。
Induction of cell-associated chemokines after endotoxin administration to healthy humans.
作者信息
Olszyna D P, De Jonge E, Dekkers P E, van Deventer S J, van der Poll T
机构信息
Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
Infect Immun. 2001 Apr;69(4):2736-8. doi: 10.1128/IAI.69.4.2736-2738.2001.
Abstract
Erythrocytes express the Duffy antigen receptor for chemokines. Endotoxin injection into humans induced high levels of interleukin-8 (IL-8), growth-related oncogene alpha, and monocyte chemoattractant protein 1 in circulating erythrocytes. IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations.
摘要
红细胞表达趋化因子的达菲抗原受体。给人类注射内毒素可诱导循环红细胞中白细胞介素-8（IL-8）、生长相关癌基因α和单核细胞趋化蛋白1的高水平表达。IL-8也可从单核细胞和多形核细胞中回收。与细胞相关的趋化因子可能比血浆浓度更准确地反映它们的产生情况。
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