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1
Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.单核细胞趋化蛋白1对肺炎球菌肺炎的保护性免疫没有作用。
Infect Immun. 2006 Dec;74(12):7021-3. doi: 10.1128/IAI.00977-06. Epub 2006 Sep 18.
2
Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae.CC趋化因子配体2依赖性肺单核吞噬细胞募集在抑制感染肺炎链球菌的小鼠败血症中起重要作用。
J Immunol. 2009 Apr 15;182(8):4931-7. doi: 10.4049/jimmunol.0804096.
3
Monocyte chemoattractant protein 1 contributes to an adequate immune response in influenza pneumonia.单核细胞趋化蛋白1有助于流感肺炎中产生充分的免疫反应。
Clin Immunol. 2007 Dec;125(3):328-36. doi: 10.1016/j.clim.2007.08.001. Epub 2007 Sep 10.
4
CD11b limits bacterial outgrowth and dissemination during murine pneumococcal pneumonia.CD11b在小鼠肺炎球菌肺炎期间限制细菌生长和扩散。
J Infect Dis. 2005 May 15;191(10):1755-60. doi: 10.1086/429633. Epub 2005 Apr 6.
5
The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.晚期糖基化终末产物受体损害肺炎球菌肺炎中的宿主防御。
J Immunol. 2009 Apr 1;182(7):4349-56. doi: 10.4049/jimmunol.0801199.
6
LPS-binding protein-deficient mice have an impaired defense against Gram-negative but not Gram-positive pneumonia.缺乏脂多糖结合蛋白的小鼠对革兰氏阴性菌引起的肺炎防御能力受损，但对革兰氏阳性菌引起的肺炎防御不受影响。
Int Immunol. 2004 Nov;16(11):1605-11. doi: 10.1093/intimm/dxh161. Epub 2004 Sep 27.
7
Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production.单核细胞趋化蛋白1/C-C趋化因子配体2缺陷小鼠对败血症和内毒素休克的易感性增加，这与白细胞介素10减少和巨噬细胞移动抑制因子产生增加有关。
Shock. 2006 Nov;26(5):457-63. doi: 10.1097/01.shk.0000228801.56223.92.
8
Toll-like receptor 2 does not contribute to host response during postinfluenza pneumococcal pneumonia.Toll样受体2在流感后肺炎球菌肺炎期间对宿主反应无作用。
Am J Respir Cell Mol Biol. 2007 May;36(5):609-14. doi: 10.1165/rcmb.2006-0166OC. Epub 2006 Dec 14.
9
Critical role of monocyte chemoattractant protein-1/CC chemokine ligand 2 in the pathogenesis of ischemic cardiomyopathy.单核细胞趋化蛋白-1/CC趋化因子配体2在缺血性心肌病发病机制中的关键作用
Circulation. 2007 Feb 6;115(5):584-92. doi: 10.1161/CIRCULATIONAHA.106.646091.
10
Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice.单核细胞趋化蛋白1对小鼠短暂性局灶性脑缺血后血源性细胞募集的影响。
Neuroscience. 2009 Jul 7;161(3):806-12. doi: 10.1016/j.neuroscience.2009.04.025. Epub 2009 Apr 15.

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1
Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia.巨噬细胞 Rac2 对于减轻香烟烟雾引起的肺炎的严重程度是必需的。
Am J Respir Crit Care Med. 2018 Nov 15;198(10):1288-1301. doi: 10.1164/rccm.201712-2388OC.
2
Polyamine transporter in Streptococcus pneumoniae is essential for evading early innate immune responses in pneumococcal pneumonia.肺炎链球菌中的多胺转运蛋白对于逃避肺炎链球菌肺炎早期的先天性免疫反应至关重要。
Sci Rep. 2016 Jun 1;6:26964. doi: 10.1038/srep26964.
3
Neutrophil depletion causes a fatal defect in murine pulmonary Staphylococcus aureus clearance.中性粒细胞耗竭会导致小鼠肺部清除金黄色葡萄球菌出现致命缺陷。
J Surg Res. 2008 Dec;150(2):278-85. doi: 10.1016/j.jss.2008.02.009. Epub 2008 Mar 13.

本文引用的文献

1
Pneumonia models and innate immunity to respiratory bacterial pathogens.肺炎模型与对呼吸道细菌病原体的固有免疫
Shock. 2005 Dec;24 Suppl 1:12-8. doi: 10.1097/01.shk.0000191385.41689.f3.
2
Novel chemokine responsiveness and mobilization of neutrophils during sepsis.脓毒症期间中性粒细胞的新型趋化因子反应性及动员
Am J Pathol. 2004 Dec;165(6):2187-96. doi: 10.1016/S0002-9440(10)63268-3.
3
Essential contribution of monocyte chemoattractant protein-1/C-C chemokine ligand-2 to resolution and repair processes in acute bacterial pneumonia.单核细胞趋化蛋白-1/C-C趋化因子配体-2在急性细菌性肺炎的消散和修复过程中的重要作用。
J Immunol. 2004 Jan 1;172(1):398-409. doi: 10.4049/jimmunol.172.1.398.
4
Monocyte chemoattractant protein-1 (CCL2) in inflammatory disease and adaptive immunity: therapeutic opportunities and controversies.炎症性疾病与适应性免疫中的单核细胞趋化蛋白-1（CCL2）：治疗机遇与争议
Microcirculation. 2003 Jun;10(3-4):247-57. doi: 10.1038/sj.mn.7800190.
5
Cytokines in innate host defense in the lung.肺部天然宿主防御中的细胞因子。
J Clin Invest. 2002 Mar;109(6):699-705. doi: 10.1172/JCI15277.
6
IL-18 improves the early antimicrobial host response to pneumococcal pneumonia.白细胞介素-18可改善机体对肺炎球菌肺炎的早期抗菌宿主反应。
J Immunol. 2002 Jan 1;168(1):372-8. doi: 10.4049/jimmunol.168.1.372.
7
TNF-alpha compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia.在肺炎球菌肺炎期间，肿瘤坏死因子-α可弥补白细胞介素-1 I型受体缺陷小鼠受损的宿主防御功能。
J Immunol. 2001 Nov 1;167(9):5240-6. doi: 10.4049/jimmunol.167.9.5240.
8
Role of chemokines and formyl peptides in pneumococcal pneumonia-induced monocyte/macrophage recruitment.趋化因子和甲酰肽在肺炎球菌肺炎诱导的单核细胞/巨噬细胞募集中的作用。
J Immunol. 2001 Jun 15;166(12):7353-61. doi: 10.4049/jimmunol.166.12.7353.
9
Induction of cell-associated chemokines after endotoxin administration to healthy humans.内毒素给予健康人后细胞相关趋化因子的诱导。
Infect Immun. 2001 Apr;69(4):2736-8. doi: 10.1128/IAI.69.4.2736-2738.2001.
10
Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4.内源性单核细胞趋化蛋白-1（MCP-1）在急性脓毒性腹膜炎模型中对小鼠具有保护作用：MCP-1与白三烯B4之间的相互作用
J Immunol. 1999 Dec 1;163(11):6148-54.

单核细胞趋化蛋白1对肺炎球菌肺炎的保护性免疫没有作用。

Monocyte chemoattractant protein 1 does not contribute to protective immunity against pneumococcal pneumonia.

作者信息

Dessing Mark C, de Vos Alex F, Florquin Sandrine, van der Poll Tom

机构信息

Center for Experimental and Molecular Medicine, Room F0-117, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

出版信息

Infect Immun. 2006 Dec;74(12):7021-3. doi: 10.1128/IAI.00977-06. Epub 2006 Sep 18.

DOI:10.1128/IAI.00977-06
PMID:16982835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1698042/
Abstract

To determine the role of monocyte chemoattractant protein 1 (MCP-1) during pneumococcal pneumonia, MCP-1 knockout and wild-type mice were infected with Streptococcus pneumoniae. Pulmonary MCP-1 levels were strongly correlated to bacterial loads in wild-type mice. However, MCP-1 knockout and wild-type mice were indistinguishable with respect to bacterial growth, inflammatory responses, and lethality.

摘要

为了确定单核细胞趋化蛋白1（MCP-1）在肺炎球菌肺炎中的作用，将MCP-1基因敲除小鼠和野生型小鼠感染肺炎链球菌。在野生型小鼠中，肺内MCP-1水平与细菌载量密切相关。然而，在细菌生长、炎症反应和致死率方面，MCP-1基因敲除小鼠和野生型小鼠并无差异。