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1
Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects.水飞蓟：对肝脏疾病和肝硬化的影响及临床不良反应
Evid Rep Technol Assess (Summ). 2000(21):1-3.
2
Review of clinical trials evaluating safety and efficacy of milk thistle (Silybum marianum [L.] Gaertn.).评价水飞蓟（水飞蓟 [L.] 盖尔特纳）安全性和有效性的临床试验综述。
Integr Cancer Ther. 2007 Jun;6(2):146-57. doi: 10.1177/1534735407301942.
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Milk thistle for the treatment of liver disease: a systematic review and meta-analysis.水飞蓟用于治疗肝脏疾病：一项系统评价与荟萃分析。
Am J Med. 2002 Oct 15;113(6):506-15. doi: 10.1016/s0002-9343(02)01244-5.
4
Milk thistle for alcoholic and/or hepatitis B or C liver diseases--a systematic cochrane hepato-biliary group review with meta-analyses of randomized clinical trials.水飞蓟用于酒精性肝病和/或乙型或丙型肝炎——Cochrane肝胆病学组的系统评价及随机临床试验的荟萃分析
Am J Gastroenterol. 2005 Nov;100(11):2583-91. doi: 10.1111/j.1572-0241.2005.00262.x.
5
By the way, doctor... My neighbor takes something called milk thistle. He likes to drink alcohol and believes the herb will protect him against any kind of liver damage. Is he right?顺便问一下，医生……我的邻居服用一种叫做水飞蓟的东西。他喜欢喝酒，并且认为这种草药能保护他免受任何肝脏损伤。他说得对吗？
Harv Health Lett. 2001 Jul;26(9):8.
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Milk thistle to treat non-alcoholic fatty liver disease: dream or reality?水飞蓟治疗非酒精性脂肪性肝病：梦想还是现实？
Expert Rev Gastroenterol Hepatol. 2013 Nov;7(8):677-9. doi: 10.1586/17474124.2013.842893. Epub 2013 Oct 17.
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A review of plants used in the treatment of liver disease: part 1.用于治疗肝病的植物综述：第1部分。
Altern Med Rev. 1998 Dec;3(6):410-21.
8
Complementary and alternative medicine in hepatology: review of the evidence of efficacy.肝病学中的补充和替代医学：疗效证据综述
Clin Gastroenterol Hepatol. 2007 Apr;5(4):408-16. doi: 10.1016/j.cgh.2006.10.014. Epub 2007 Jan 11.
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Advances in the use of milk thistle (Silybum marianum).水飞蓟（奶蓟草，Silybum marianum）的应用进展。
Integr Cancer Ther. 2007 Jun;6(2):104-9. doi: 10.1177/1534735407301632.
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[Balsam for the liver].[肝脏香脂]
Praxis (Bern 1994). 2004 Sep 1;93(36):1472.

引用本文的文献

1
Are alterations needed in Silybum marianum (Silymarin) administration practices? A novel outlook and meta-analysis on randomized trials targeting liver injury.水飞蓟（水飞蓟素）的给药方法是否需要改变？针对肝损伤的随机试验的新观点和荟萃分析。
BMC Complement Med Ther. 2025 Apr 12;25(1):134. doi: 10.1186/s12906-025-04886-y.
2
A Silibinin-Poly(ε-Caprolactone) Conjugate as an Enhanced Anticancer Agent.一种作为增强型抗癌剂的水飞蓟宾-聚（ε-己内酯）共轭物
Macromol Biosci. 2025 Apr;25(4):e2400510. doi: 10.1002/mabi.202400510. Epub 2025 Feb 12.
3
Novel Strategies Enhancing Bioavailability and Therapeutical Potential of Silibinin for Treatment of Liver Disorders.新型策略增强水飞蓟宾生物利用度及其治疗肝脏疾病的治疗潜力。
Drug Des Devel Ther. 2024 Oct 19;18:4629-4659. doi: 10.2147/DDDT.S483140. eCollection 2024.
4
Comparing the extraction methods, chemical composition, phenolic contents and antioxidant activity of edible oils from Cannabis sativa and Silybum marianu seeds.比较大麻（Cannabis sativa）和水飞蓟（Silybum marianu）种子食用油的提取方法、化学成分、酚类含量和抗氧化活性。
Sci Rep. 2022 Nov 29;12(1):20609. doi: 10.1038/s41598-022-25030-7.
5
Regulatory Networks, Management Approaches, and Emerging Treatments of Nonalcoholic Fatty Liver Disease.非酒精性脂肪性肝病的调控网络、管理方法和新兴治疗方法。
Can J Gastroenterol Hepatol. 2022 Nov 8;2022:6799414. doi: 10.1155/2022/6799414. eCollection 2022.
6
Silibinin sensitizes chemo-resistant breast cancer cells to chemotherapy.水飞蓟宾使化疗耐药的乳腺癌细胞对化疗敏感。
Pharm Biol. 2017 Dec;55(1):729-739. doi: 10.1080/13880209.2016.1270972.
7
Effects and tolerance of silymarin (milk thistle) in chronic hepatitis C virus infection patients: a meta-analysis of randomized controlled trials.水飞蓟素（奶蓟）对慢性丙型肝炎病毒感染患者的疗效及耐受性：一项随机对照试验的荟萃分析
Biomed Res Int. 2014;2014:941085. doi: 10.1155/2014/941085. Epub 2014 Aug 27.
8
A randomized controlled trial to assess the safety and efficacy of silymarin on symptoms, signs and biomarkers of acute hepatitis.一项评估水飞蓟素对急性肝炎症状、体征及生物标志物的安全性和疗效的随机对照试验。
Phytomedicine. 2009 May;16(5):391-400. doi: 10.1016/j.phymed.2009.02.002. Epub 2009 Mar 19.
9
Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases.水飞蓟用于治疗酒精性肝病和/或乙型或丙型肝炎病毒引起的肝病。
Cochrane Database Syst Rev. 2007 Oct 17;2007(4):CD003620. doi: 10.1002/14651858.CD003620.pub3.
10
Herbal supplements.草药补充剂。
Curr Gastroenterol Rep. 2005 Aug;7(4):302-7. doi: 10.1007/s11894-005-0023-z.

Milk thistle: effects on liver disease and cirrhosis and clinical adverse effects.

作者信息

Mulrow C, Lawrence V, Jacobs B, Dennehy C, Sapp J, Ramirez G, Aguilar C, Montgomery K, Morbidoni L, Arterburn J M, Chiquette E, Harris M, Mullins D, Vickers A, Flora K

出版信息

Evid Rep Technol Assess (Summ). 2000(21):1-3.

PMID:11262867
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4781343/
Abstract
摘要