di Gennaro G, Canzonieri V, Schioppa O, Nasti G, Carbone A, Tirelli U
Division of Medical Oncology A, National Cancer Institute, Aviano, Italy.
Clin Infect Dis. 2001 Apr 1;32(7):1100-2. doi: 10.1086/319603. Epub 2001 Mar 15.
Human herpesvirus 8 (HHV8), which has been suggested as the causal agent of Kaposi's sarcoma (KS), has also been implicated in the pathogenesis of sarcoidosis. We describe a patient affected concomitantly by sarcoidosis and KS. HHV8 sequences were detected with PCR only on KS lesions, whereas sarcoid tissues did not harbor HHV8 DNA. Immune dysfunction related to sarcoidosis may have facilitated the oncogenic role of HHV8 and the development of KS.
人类疱疹病毒8型（HHV8）被认为是卡波西肉瘤（KS）的致病因子，也与结节病的发病机制有关。我们描述了一名同时患有结节病和KS的患者。仅在KS病变中通过PCR检测到HHV8序列，而结节病组织中未检测到HHV8 DNA。与结节病相关的免疫功能障碍可能促进了HHV8的致癌作用及KS的发生。
