Berardini T Z, Bollman K, Sun H, Poethig R S
Plant Science Institute, Department of Biology, University of Pennsylvania, Philadelphia, PA 19104-6018, USA.
Science. 2001 Mar 23;291(5512):2405-7. doi: 10.1126/science.1057144.
During its development, a plant shoot progresses from a juvenile to an adult phase of vegetative growth and from a reproductively incompetent to a reproductively competent state. In Arabidopsis, loss-of-function mutations in SQUINT (SQN) reduced the number of juvenile leaves and had subtle effects on inflorescence morphology but had no effect on flowering time or on reproductive competence. SQN encodes the Arabidopsis homolog of cyclophilin 40 (CyP40), a protein found in association with the Hsp90 chaperone complex in yeast, mammals, and plants. Thus, in Arabidopsis, CyP40 is specifically required for the vegetative but not the reproductive maturation of the shoot.
在植物发育过程中，茎尖从幼年营养生长阶段过渡到成年营养生长阶段，从生殖无能力状态转变为生殖有能力状态。在拟南芥中，斜视（SQN）功能丧失突变减少了幼叶数量，对花序形态有细微影响，但对开花时间或生殖能力没有影响。SQN编码亲环蛋白40（CyP40）的拟南芥同源物，该蛋白在酵母、哺乳动物和植物中与热休克蛋白90（Hsp90）伴侣复合体相关联。因此，在拟南芥中，CyP40是茎尖营养成熟而非生殖成熟所特需的。
