果蝇中多巴脱羧酶活性对基因剂量变化的反应：结构基因的可能位置。
The response of dopa decarboxylase activity to variations in gene dosage in Drosophila: a possible location of the structural gene.
作者信息
Hodgetts R B
出版信息
Genetics. 1975 Jan;79(1):45-54. doi: 10.1093/genetics/79.1.45.
Abstract
A location of the structural gene(s) for dopa decarboxylase (EC 4.1.1.26) is proposed on the basis of enzyme determinations in a set of duplication-bearing aneuploids, which revealed only one dosage-sensitive region in the Drosophila genome. This region lies between 36EF and 37D on the left arm of chromosome 2.
摘要
基于对一组带有重复片段的非整倍体的酶活性测定，提出了多巴脱羧酶（EC 4.1.1.26）结构基因的定位，结果显示果蝇基因组中只有一个剂量敏感区域。该区域位于2号染色体左臂的36EF和37D之间。
相似文献
1
The response of dopa decarboxylase activity to variations in gene dosage in Drosophila: a possible location of the structural gene.果蝇中多巴脱羧酶活性对基因剂量变化的反应：结构基因的可能位置。
Genetics. 1975 Jan;79(1):45-54. doi: 10.1093/genetics/79.1.45.
2
The genetics of dopa decarboxylase in Drosophila melanogaster. I. Isolation and characterization of deficiencies that delete the dopa-decarboxylase-dosage-sensitive region and the alpha-methyl-dopa-hypersensitive locus.黑腹果蝇中多巴脱羧酶的遗传学。I. 缺失多巴脱羧酶剂量敏感区域和α-甲基多巴超敏位点的缺陷型的分离与特性分析。
Genetics. 1976 Oct;84(2):267-85. doi: 10.1093/genetics/84.2.267.
3
The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants.黑腹果蝇中多巴脱羧酶的遗传学。II. 多巴脱羧酶缺陷型突变体的分离与鉴定及其与α-甲基多巴超敏突变体的关系。
Genetics. 1976 Oct;84(2):287-310. doi: 10.1093/genetics/84.2.287.
4
Segmental aneuploidy and the genetic gross structure of the Drosophila genome.节段性非整倍体与果蝇基因组的遗传总体结构。
Genetics. 1972 May;71(1):157-84. doi: 10.1093/genetics/71.1.157.
5
The analog inhibitor, alpha-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase activity in Drosophila melanogaster.模拟抑制剂α-甲基多巴作为筛选果蝇中提高多巴脱羧酶活性水平突变体的试剂。
Mol Gen Genet. 1974;133(1):25-36. doi: 10.1007/BF00268674.
6
A kinetic analysis of Drosophila melanogaster dopa decarboxylase.黑腹果蝇多巴脱羧酶的动力学分析
Biochim Biophys Acta. 1986 Mar 7;870(1):31-40. doi: 10.1016/0167-4838(86)90005-1.
7
The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor.对α-甲基多巴（一种多巴脱羧酶抑制剂）敏感的黑腹果蝇突变体的筛选。
Mol Gen Genet. 1974 May 21;130(2):127-41. doi: 10.1007/BF00269084.
8
Evidence for evolutionary duplication of genes in the dopa decarboxylase region of Drosophila.果蝇多巴脱羧酶区域基因进化复制的证据。
Genetics. 1986 Oct;114(2):469-83. doi: 10.1093/genetics/114.2.469.
9
Isolation and characterization of the dopa decarboxylase gene of Drosophila melanogaster.黑腹果蝇多巴脱羧酶基因的分离与鉴定
Mol Cell Biol. 1981 Jun;1(6):475-85. doi: 10.1128/mcb.1.6.475-485.1981.
10
Tyrosine decarboxylase and dopa decarboxylase in Drosophila virilis under normal conditions and heat stress: genetic and physiological aspects.正常条件和热应激下果蝇的酪氨酸脱羧酶和多巴脱羧酶：遗传和生理方面
Biochem Genet. 1997 Apr;35(3-4):91-103. doi: 10.1023/a:1022209707655.
引用本文的文献
1
Facts and artifacts in studies of gene expression in aneuploids and sex chromosomes.非整倍体和性染色体基因表达研究中的事实与假象
Chromosoma. 2014 Oct;123(5):459-69. doi: 10.1007/s00412-014-0478-5. Epub 2014 Jul 29.
2
Dosage compensation and inverse effects in triple X metafemales of Drosophila.果蝇三倍 X 超雌代的剂量补偿和反效作用。
Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7383-8. doi: 10.1073/pnas.1305638110. Epub 2013 Apr 15.
3
Gene balance hypothesis: connecting issues of dosage sensitivity across biological disciplines.基因平衡假说：连接各生物学科剂量敏感性问题。
Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14746-53. doi: 10.1073/pnas.1207726109. Epub 2012 Aug 20.
4
Identification of Inverse Regulator-a (Inr-a) as Synonymous with Pre-mRNA Cleavage Complex II Protein (Pcf11) in Drosophila.鉴定果蝇中的反式作用因子 a（Inr-a）与前体 mRNA 切割复合物 II 蛋白（Pcf11）同义。
G3 (Bethesda). 2012 Jun;2(6):701-6. doi: 10.1534/g3.112.002071. Epub 2012 Jun 1.
5
Modulation of protein levels in chromosomal dosage series of maize: the biochemical basis of aneuploid syndromes.玉米染色体剂量系列中蛋白质水平的调节：非整倍体综合征的生化基础。
Genetics. 1981 Oct;99(2):247-66. doi: 10.1093/genetics/99.2.247.
6
Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster.无雄突变对黑腹果蝇X染色体和常染色体基因表达的影响。
Genetics. 1994 Mar;136(3):913-26. doi: 10.1093/genetics/136.3.913.
7
A method for assaying DNA-dependent RNA polymerase II in crude extracts of Drosophila melanogaster adults: its use in identifying mutants with an altered RNA polymerase II.一种用于测定黑腹果蝇成虫粗提物中DNA依赖性RNA聚合酶II的方法：其在鉴定RNA聚合酶II发生改变的突变体中的应用。
Biochem Genet. 1981 Feb;19(1-2):31-46. doi: 10.1007/BF00486135.
8
Induction of translatable mRNA for dopa decarboxylase in Drosophila: an early response to ecdysterone.果蝇中多巴脱羧酶可翻译mRNA的诱导：对蜕皮激素的早期反应。
Proc Natl Acad Sci U S A. 1980 Jul;77(7):4175-9. doi: 10.1073/pnas.77.7.4175.
9
Cytogenetic localization by variation in electrophoretic allozyme phenotype: Drosophila Odh.通过电泳等位酶表型变异进行细胞遗传学定位：果蝇苹果酸脱氢酶
Biochem Genet. 1983 Apr;21(3-4):375-90. doi: 10.1007/BF00499146.
10
Isolation and characterization of the dopa decarboxylase gene of Drosophila melanogaster.黑腹果蝇多巴脱羧酶基因的分离与鉴定
Mol Cell Biol. 1981 Jun;1(6):475-85. doi: 10.1128/mcb.1.6.475-485.1981.
本文引用的文献
1
Studies on the genetic control of tryptophan pyrrolase in Drosophila melanogaster.黑腹果蝇中色氨酸吡咯酶的遗传控制研究。
Mol Gen Genet. 1971;112(4):341-53. doi: 10.1007/BF00334435.
2
Segmental aneuploidy and the genetic gross structure of the Drosophila genome.节段性非整倍体与果蝇基因组的遗传总体结构。
Genetics. 1972 May;71(1):157-84. doi: 10.1093/genetics/71.1.157.
3
Tyrosine and catecholamine metabolism in wild-type Drosophila melanogaster and a mutant, ebony.野生型黑腹果蝇和突变体乌木体果蝇中的酪氨酸和儿茶酚胺代谢
J Insect Physiol. 1973 Jun;19(6):1211-20. doi: 10.1016/0022-1910(73)90205-9.
Zotero 插件