鼠疫耶尔森氏菌临床分离株中可转移的质粒介导的链霉素抗性
Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.
作者信息
Guiyoule A, Gerbaud G, Buchrieser C, Galimand M, Rahalison L, Chanteau S, Courvalin P, Carniel E
机构信息
Laboratoire des Yersinia, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris, France.
出版信息
Emerg Infect Dis. 2001 Jan-Feb;7(1):43-8. doi: 10.3201/eid0701.010106.
Abstract
Plasmid-mediated high-level resistance to multiple antibiotics was reported in a clinical isolate of Yersinia pestis in Madagascar in 1997. We describe a second Y. pestis strain with high-level resistance to streptomycin, isolated from a human case of bubonic plague in Madagascar. The resistance determinants were carried by a self-transferable plasmid that could conjugate at high frequencies to other Y. pestis isolates. The plasmid and the host bacterium were different from those previously associated with multiple-drug resistance, indicating that acquisition of resistance plasmids is occurring in this bacterial species. Emergence of resistance to streptomycin in Y. pestis represents a critical public health problem since this antibiotic is used as the first-line treatment against plague in many countries.
摘要
1997年在马达加斯加的一株鼠疫耶尔森菌临床分离株中报告了质粒介导的对多种抗生素的高水平耐药性。我们描述了从马达加斯加一名腺鼠疫患者身上分离出的另一株对链霉素具有高水平耐药性的鼠疫耶尔森菌菌株。耐药决定因子由一个可自我转移的质粒携带，该质粒可高频接合到其他鼠疫耶尔森菌分离株。该质粒和宿主细菌与先前与多重耐药性相关的质粒和细菌不同，这表明该细菌物种中正在发生耐药性质粒的获得。鼠疫耶尔森菌对链霉素耐药性的出现是一个关键的公共卫生问题，因为在许多国家这种抗生素被用作鼠疫的一线治疗药物。
相似文献
1
Transferable plasmid-mediated resistance to streptomycin in a clinical isolate of Yersinia pestis.鼠疫耶尔森氏菌临床分离株中可转移的质粒介导的链霉素抗性
Emerg Infect Dis. 2001 Jan-Feb;7(1):43-8. doi: 10.3201/eid0701.010106.
2
Plasmid-mediated doxycycline resistance in a Yersinia pestis strain isolated from a rat.质粒介导的强力霉素耐药性在一株从大鼠中分离的鼠疫耶尔森氏菌菌株中。
Int J Antimicrob Agents. 2018 Feb;51(2):249-254. doi: 10.1016/j.ijantimicag.2017.09.015. Epub 2017 Oct 10.
3
A novel mechanism of streptomycin resistance in Yersinia pestis: Mutation in the rpsL gene.鼠疫耶尔森氏菌链霉素耐药的新机制：rpsL 基因突变。
PLoS Negl Trop Dis. 2021 Apr 22;15(4):e0009324. doi: 10.1371/journal.pntd.0009324. eCollection 2021 Apr.
4
Vibrio cholerae O139 multiple-drug resistance mediated by Yersinia pestis pIP1202-like conjugative plasmids.由鼠疫耶尔森菌pIP1202样接合质粒介导的霍乱弧菌O139多重耐药性。
Antimicrob Agents Chemother. 2008 Nov;52(11):3829-36. doi: 10.1128/AAC.00375-08. Epub 2008 Aug 18.
5
High-frequency conjugative transfer of antibiotic resistance genes to Yersinia pestis in the flea midgut.抗生素抗性基因在跳蚤中肠向鼠疫耶尔森菌的高频接合转移。
Mol Microbiol. 2002 Oct;46(2):349-54. doi: 10.1046/j.1365-2958.2002.03159.x.
6
Novel plasmids and resistance phenotypes in Yersinia pestis: unique plasmid inventory of strain Java 9 mediates high levels of arsenic resistance.鼠疫耶尔森氏菌中新的质粒和耐药表型：强砷抗性的 Java 9 株具有独特的质粒谱。
PLoS One. 2012;7(3):e32911. doi: 10.1371/journal.pone.0032911. Epub 2012 Mar 30.
7
Comparative efficacies of candidate antibiotics against Yersinia pestis in an in vitro pharmacodynamic model.候选抗生素在体外药效模型中抗鼠疫耶尔森菌的比较疗效。
Antimicrob Agents Chemother. 2011 Jun;55(6):2623-8. doi: 10.1128/AAC.01374-10. Epub 2011 Apr 12.
8
Multiple antimicrobial resistance in plague: an emerging public health risk.鼠疫中的多重抗菌药物耐药性：一个新出现的公共卫生风险。
PLoS One. 2007 Mar 21;2(3):e309. doi: 10.1371/journal.pone.0000309.
9
Use of an in vitro pharmacodynamic model to derive a moxifloxacin regimen that optimizes kill of Yersinia pestis and prevents emergence of resistance.利用体外药效动力学模型制定优化鼠疫耶尔森菌杀伤并防止耐药性出现的莫西沙星方案。
Antimicrob Agents Chemother. 2011 Feb;55(2):822-30. doi: 10.1128/AAC.00818-10. Epub 2010 Nov 29.
10
Recent emergence of new variants of Yersinia pestis in Madagascar.马达加斯加近期出现鼠疫耶尔森菌新变种。
J Clin Microbiol. 1997 Nov;35(11):2826-33. doi: 10.1128/jcm.35.11.2826-2833.1997.
引用本文的文献
1
Nanolipoprotein particle (NLP) vaccine confers protection against aerosol challenge in a BALB/c mouse model.纳米脂蛋白颗粒（NLP）疫苗在BALB/c小鼠模型中可提供针对气溶胶攻击的保护作用。
Front Immunol. 2025 Jun 26;16:1603710. doi: 10.3389/fimmu.2025.1603710. eCollection 2025.
2
Assessing the threat of harboring a multi-resistant IncC plasmid and the efficacy of an antibiotic targeting LpxC.评估携带多重耐药性IncC质粒的威胁以及一种靶向LpxC的抗生素的疗效。
Antimicrob Agents Chemother. 2025 Mar 5;69(3):e0149724. doi: 10.1128/aac.01497-24. Epub 2025 Jan 30.
3
Development of Effective Medical Countermeasures Against the Main Biowarfare Agents: The Importance of Antibodies.针对主要生物战剂的有效医学应对措施的研发：抗体的重要性
Microorganisms. 2024 Dec 18;12(12):2622. doi: 10.3390/microorganisms12122622.
4
Design of a novel multi-epitope vaccine candidate against using advanced immunoinformatics approaches: An in silico study.使用先进免疫信息学方法设计一种针对[具体疾病或病原体未提及]的新型多表位疫苗候选物：一项计算机模拟研究。
Biochem Biophys Rep. 2024 Nov 18;40:101871. doi: 10.1016/j.bbrep.2024.101871. eCollection 2024 Dec.
5
Progress on the research and development of plague vaccines with a call to action.鼠疫疫苗研发进展及行动呼吁
NPJ Vaccines. 2024 Sep 7;9(1):162. doi: 10.1038/s41541-024-00958-1.
6
Exploring and Mitigating Plague for One Health Purposes.为实现“同一健康”目标探索并减轻鼠疫危害
Curr Trop Med Rep. 2022;9(4):169-184. doi: 10.1007/s40475-022-00265-6.
7
Evaluation of human antibodies from vaccinated volunteers for protection against infection.评估接种疫苗的志愿者体内的人抗体，以预防感染。
Microbiol Spectr. 2024 Oct 3;12(10):e0105424. doi: 10.1128/spectrum.01054-24. Epub 2024 Aug 27.
8
Review of genotyping methods for Yersinia pestis in Madagascar.马达加斯加鼠疫耶尔森菌基因分型方法的研究综述。
PLoS Negl Trop Dis. 2024 Jun 27;18(6):e0012252. doi: 10.1371/journal.pntd.0012252. eCollection 2024 Jun.
9
Short-chain fatty acids inhibit bacterial plasmid transfer through conjugation and in chicken tissue explants.短链脂肪酸在鸡组织外植体中通过接合作用抑制细菌质粒转移。
Front Microbiol. 2024 Jun 6;15:1414401. doi: 10.3389/fmicb.2024.1414401. eCollection 2024.
10
Phylogenetic Relationships and Evolution of the Genus (186-Type) Bacteriophages.（186 型）噬菌体属的系统发育关系和进化。
Viruses. 2024 May 8;16(5):748. doi: 10.3390/v16050748.
本文引用的文献
1
Complete sequence of the IncPbeta plasmid R751: implications for evolution and organisation of the IncP backbone.IncPβ质粒R751的完整序列：对IncP主干结构的进化与组织的启示
J Mol Biol. 1998 Oct 9;282(5):969-90. doi: 10.1006/jmbi.1998.2060.
2
Recent emergence of new variants of Yersinia pestis in Madagascar.马达加斯加近期出现鼠疫耶尔森菌新变种。
J Clin Microbiol. 1997 Nov;35(11):2826-33. doi: 10.1128/jcm.35.11.2826-2833.1997.
3
Multidrug resistance in Yersinia pestis mediated by a transferable plasmid.鼠疫耶尔森菌中由可转移质粒介导的多药耐药性。
N Engl J Med. 1997 Sep 4;337(10):677-80. doi: 10.1056/NEJM199709043371004.
4
In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus.14种抗生素对来自非洲南部鼠疫疫源地的100株人源鼠疫耶尔森菌的体外活性
Antimicrob Agents Chemother. 1996 Nov;40(11):2646-7. doi: 10.1128/AAC.40.11.2646.
5
In vitro antimicrobial susceptibilities of strains of Yersinia pestis.鼠疫耶尔森菌菌株的体外抗菌药敏情况
Antimicrob Agents Chemother. 1995 Sep;39(9):2153-4. doi: 10.1128/AAC.39.9.2153.
6
Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes.氨基糖苷类耐药基因的分子遗传学及氨基糖苷类修饰酶的家族关系。
Microbiol Rev. 1993 Mar;57(1):138-63. doi: 10.1128/mr.57.1.138-163.1993.
7
Nucleotide sequence analysis of a transposon (Tn5393) carrying streptomycin resistance genes in Erwinia amylovora and other gram-negative bacteria.对梨火疫病菌及其他革兰氏阴性菌中携带链霉素抗性基因的转座子（Tn5393）进行核苷酸序列分析。
J Bacteriol. 1993 Feb;175(3):732-40. doi: 10.1128/jb.175.3.732-740.1993.
8
Expression of the strA-strB streptomycin resistance genes in Pseudomonas syringae and Xanthomonas campestris and characterization of IS6100 in X. campestris.丁香假单胞菌和野油菜黄单胞菌中strA-strB链霉素抗性基因的表达以及野油菜黄单胞菌中IS6100的特性分析。
Appl Environ Microbiol. 1995 Aug;61(8):2891-7. doi: 10.1128/aem.61.8.2891-2897.1995.
9
Plasmids in Yersinia pestis.鼠疫耶尔森氏菌中的质粒
Infect Immun. 1981 Feb;31(2):839-41. doi: 10.1128/iai.31.2.839-841.1981.
10
Host specificity of DNA produced by Escherichia coli: bacterial mutations affecting the restriction and modification of DNA.大肠杆菌产生的DNA的宿主特异性：影响DNA限制与修饰的细菌突变
J Mol Biol. 1966 Mar;16(1):118-33. doi: 10.1016/s0022-2836(66)80267-x.
Zotero 插件