14种抗生素对来自非洲南部鼠疫疫源地的100株人源鼠疫耶尔森菌的体外活性
In vitro activities of 14 antibiotics against 100 human isolates of Yersinia pestis from a southern African plague focus.
作者信息
Frean J A, Arntzen L, Capper T, Bryskier A, Klugman K P
机构信息
Department of Medical Microbiology, School of Pathology, South African Institute for Medical Research, Johannesburg, South Africa.
出版信息
Antimicrob Agents Chemother. 1996 Nov;40(11):2646-7. doi: 10.1128/AAC.40.11.2646.
Abstract
A limited repertoire of antimicrobial agents is currently in use for the treatment of plague. We investigated the in vitro activities of some newer antimicrobial agents against Yersinia pestis. Among the injectable agents tested, cefotaxime was the most active, and among the oral agents, both levofloxacin and ofloxacin were highly active, with MICs at which 90% of isolates are inhibited of < 0.03 microgram/ml. the susceptibilities to the ketolide RU004 and the penem faropenem warrant attention. The enhanced activities of quinolones against Y. pestis suggest that these agents should be further investigated for the treatment of human plague in the future.
摘要
目前用于治疗鼠疫的抗菌药物种类有限。我们研究了一些新型抗菌药物对鼠疫耶尔森菌的体外活性。在所测试的注射用药物中，头孢噻肟活性最强，在口服药物中，左氧氟沙星和氧氟沙星均具有高活性，90%分离株被抑制的最低抑菌浓度（MIC）<0.03微克/毫升。酮内酯类药物RU004和青霉烯类药物法罗培南的敏感性值得关注。喹诺酮类药物对鼠疫耶尔森菌增强的活性表明，未来应对这些药物治疗人类鼠疫进行进一步研究。
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本文引用的文献
1
Modern therapy of plague.鼠疫的现代疗法。
J Am Med Assoc. 1950 Nov 18;144(12):982-5. doi: 10.1001/jama.1950.02920120006003.
2
Doxycycline or ciprofloxacin prophylaxis and therapy against experimental Yersinia pestis infection in mice.强力霉素或环丙沙星对小鼠实验性鼠疫耶尔森菌感染的预防和治疗作用
J Antimicrob Chemother. 1996 Apr;37(4):769-74. doi: 10.1093/jac/37.4.769.
3
Assessment of a fluoroquinolone, three beta-lactams, two aminoglycosides, and a cycline in treatment of murine Yersinia pestis infection.评估一种氟喹诺酮、三种β-内酰胺类抗生素、两种氨基糖苷类抗生素和一种四环素对小鼠鼠疫耶尔森菌感染的治疗效果。
Antimicrob Agents Chemother. 1994 Mar;38(3):481-6. doi: 10.1128/AAC.38.3.481.
4
Plague in India.
BMJ. 1994 Oct 8;309(6959):893-4. doi: 10.1136/bmj.309.6959.893.
5
Yersinia infections: centennial of the discovery of the plague bacillus.耶尔森菌感染：鼠疫杆菌发现一百周年
Clin Infect Dis. 1994 Oct;19(4):655-61; quiz 662-3. doi: 10.1093/clinids/19.4.655.
6
Bubonic plague outbreak in Mozambique, 1994.
Lancet. 1995 Apr 15;345(8955):983-4. doi: 10.1016/s0140-6736(95)90730-0.
7
Application of enzyme immunoassays for the confirmation of clinically suspect plague in Namibia, 1982.1982年酶免疫测定法在纳米比亚临床疑似鼠疫确诊中的应用
Bull World Health Organ. 1986;64(5):745-52.
8
The possible role of quinolones in yersiniosis.喹诺酮类药物在耶尔森菌病中的可能作用。
Drugs. 1987;34 Suppl 1:134-8. doi: 10.2165/00003495-198700341-00029.
9
[Sensitivity of Yersinia pestis to antibiotics: 277 strains isolated in Madagascar between 1926 and 1989].[鼠疫耶尔森菌对抗生素的敏感性：1926年至1989年间在马达加斯加分离出的277株菌株]
Arch Inst Pasteur Madagascar. 1989;56(1):37-53.
10
Failure of beta-lactam antibiotics and marked efficacy of fluoroquinolones in treatment of murine Yersinia pseudotuberculosis infection.β-内酰胺类抗生素治疗小鼠假结核耶尔森菌感染失败，而氟喹诺酮类药物疗效显著。
Antimicrob Agents Chemother. 1991 Sep;35(9):1785-90. doi: 10.1128/AAC.35.9.1785.
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