Adebonojo F O
In Vitro. 1975 Jan-Feb;11(1):50-4. doi: 10.1007/BF02615322.
Two theories have been advanced to explain the origin of adipocytes and both have experimental evidence in support. One theory proposed that adipocytes are specialized differentiated cells with specific lipid storage functions. The other held that they are unspecialized anlage cells which have the potential to store lipids depending on conditions. In an attempt to examine the little understood roles which these cells play in obesity and other abnormalities of lipid metabolism, disaggregated human adipocytes from infants and young children, free of stromal contamination, have been successfully grown in culture. The details of the techniques used, and some peculiar morphological characteristics of these cells in culture, are described.
已经提出了两种理论来解释脂肪细胞的起源，并且都有实验证据支持。一种理论认为脂肪细胞是具有特定脂质储存功能的特化分化细胞。另一种理论则认为它们是未特化的原基细胞，根据条件有储存脂质的潜力。为了研究这些细胞在肥胖和其他脂质代谢异常中所起的鲜为人知的作用，已经成功地在培养中培养了来自婴幼儿且无基质污染的分散人脂肪细胞。本文描述了所使用技术的细节以及这些细胞在培养中的一些特殊形态特征。
