Li M, Lu S, Ji C, Wang M, Cheng S, Jin C
Sci Sin. 1979 Apr;22(4):471-7.
DMNA, DENA and MBNA are formed in corn-bread which has been inoculated with the most common species of fungi found in foodstuffs of Lin Xian County, Henan Province, such as F. moniliforme, A. flavus and others, and then, added with small amount of NaNO2 after a few days of incubation. These carcinogenic N-nitroso compounds can induce cancer of the liver or/and esophagus in experimental animals. Results of the present study show the capability of some fungi to produce chemical carcinogens as well as mycotoxins in contaminated food, and thus, open a new field of research in cancer etiology.
二甲基亚硝胺（DMNA）、二乙基亚硝胺（DENA）和甲基苄基亚硝胺（MBNA）是在接种了河南省林县食品中常见的真菌种类（如串珠镰刀菌、黄曲霉等）的玉米面包中形成的，在培养几天后再添加少量亚硝酸钠。这些致癌的N-亚硝基化合物可在实验动物中诱发肝癌或/和食道癌。本研究结果表明，一些真菌在受污染的食物中能够产生化学致癌物以及霉菌毒素，从而开辟了癌症病因学研究的新领域。
