Shixin L, Mingxin L, Chuan J, Mingyao W, Yinglin W, Liang H
Sci Sin. 1979 May;22(5):601-7.
A new N--nitroso compound, N--1--methylacetonyl--N--3--methylbutylnitrosamine (MAMBNA) is found in corn-bread inoculated with the common fungi, such as Fusarium moniliforme, Geotrichun candidum, Aspergillus terreus or A. flavipes, encountered in food of Lin Xian County, Henan Province. The preliminary identification of this compound with TLC has been confirmed by GC-MS analysis. Furthermore, we have synthesized the MAMBNA and the chemical analysis shows that it is identical with the MAMBNA isolated from the corn-bread extract. In addition to the MAMBNA, dimethylnitrosamine, diethylnitrosamine and methylbenzylnitrosamine are formed also in the fungus-inoculated corn-bread after 8-day incubation and an addition of a small amount of sodium nitrite. The presence of precursor compounds for the formation of nitrosamine in the mouldy maize flour and their significance in respect to the etiology of esophageal cancer in high-risk areas have been discussed.
在河南省林县食品中常见的真菌，如串珠镰刀菌、白地霉、土曲霉或黄柄曲霉接种的玉米面包中，发现了一种新的N-亚硝基化合物，N-1-甲基丙酮基-N-3-甲基丁基亚硝胺（MAMBNA）。通过气相色谱-质谱分析证实了用薄层色谱法对该化合物的初步鉴定。此外，我们合成了MAMBNA，化学分析表明它与从玉米面包提取物中分离出的MAMBNA相同。除了MAMBNA，在接种真菌的玉米面包中添加少量亚硝酸钠并孵育8天后，还会形成二甲基亚硝胺、二乙基亚硝胺和甲基苄基亚硝胺。讨论了发霉玉米粉中亚硝胺形成前体化合物的存在及其在高危地区食管癌病因学中的意义。
