Smith C J, Perfetti T A, Rumple M A, Rodgman A, Doolittle D J
Research & Development, Bowman Gray Technical Center, R.J. Reynolds Tobacco Company, Winston-Salem, NC 27102, USA.
Food Chem Toxicol. 2001 Feb;39(2):183-205. doi: 10.1016/s0278-6915(00)00164-2.
In the third and final part of a series surveying the international literature on the "IARC carcinogens" in cigarette mainstream smoke, the "IARC Group 2B carcinogens" are reviewed. A search of the published literature shows that of 227 chemical components classified as Group 2B, that is, "possible carcinogens," by the International Agency for Research on Cancer (IARC), 48 have previously been reported in cigarette mainstream smoke. Owing to its highly interactive molecular nature, removal from or inhibition of a given mutagenic or carcinogenic chemical within the complex aerosol mixture cannot reliably be predicted to reduce either the overall mutagenicity or carcinogenicity. However, in the absence of experimental data demonstrating an increase in adverse biological activity resulting from removal or inhibition of a potentially carcinogenic constituent, negation of the activity of the potential carcinogen may be considered as a desirable circumstance.
在一项调查香烟主流烟雾中“国际癌症研究机构（IARC）致癌物”国际文献的系列研究的第三部分也是最后一部分中，对“IARC 2B类致癌物”进行了综述。对已发表文献的检索表明，在国际癌症研究机构（IARC）归类为2B类即“可能致癌物”的227种化学成分中，此前已有48种在香烟主流烟雾中被报道。由于其高度相互作用的分子性质，无法可靠预测从复杂的气溶胶混合物中去除或抑制某一特定诱变或致癌化学物质会降低整体诱变性或致癌性。然而，在缺乏实验数据证明去除或抑制潜在致癌成分会导致不良生物活性增加的情况下，否定潜在致癌物的活性可被视为一种理想情况。
