Kazanowska-Dygdała Magdalena, Duś Irena, Radwan-Oczko Małgorzata
Unit of Oral Pathology, Department of Periodontology, Wroclaw Medical University, Wrocław, Poland.
J Appl Oral Sci. 2016 Jan-Feb;24(1):18-23. doi: 10.1590/1678-775720150203.
Helicobacter pylori infection is one of the most common bacterial infections in men. This gastrointestinal pathogen is closely related to gastritis, peptic ulcers, and the increased risk of gastric cancer. Numerous studies have indicated oral cavities as possible Helicobacter pylori reservoirs. Helicobacter pylori has been detected both in supragingival and subgingival plaques, and also in saliva. In addition, the relationship between lesions of oral mucosa and the presence of H. pylori has been evaluated and described in some studies. The aim of this study was to assess the presence of Helicobacter pylori DNA in the oral cavity of patients with oral leukoplakia and oral lichen planus.
The study included 54 patients with oral leukoplakia, 72 with oral lichen planus lesions, and 40 healthy controls. The presence of Helicobacter pylori in oral cavity samples was analyzed using a single-step Polymerase Chain Reaction (PCR) method. All patients underwent a periodontal examination and the following clinical parameters were collected: pocket depth, bleeding, and plaque indexes. The periodontal status was assessed using the Offenbacher classification.
In most patients, pathological lesions were in typical sites on the buccal mucosa (leukoplakia in 88%, and oral lichen planus in 93% of patients). The DNA of the Helicobacter pylori was present in 20% of patients with leukoplakia and 23% of patients with lichen planus. We did not find the DNA of H. pylori in healthy controls. The periodontal status described by periodontal indices was worse in the investigated group than in the control group.
These findings suggest that the H. pylori presence in oral cavities may be related with leukoplakia and lichen planus oral lesions.
幽门螺杆菌感染是男性中最常见的细菌感染之一。这种胃肠道病原体与胃炎、消化性溃疡以及胃癌风险增加密切相关。众多研究表明口腔可能是幽门螺杆菌的储存库。已在龈上和龈下菌斑以及唾液中检测到幽门螺杆菌。此外，一些研究还评估并描述了口腔黏膜病变与幽门螺杆菌存在之间的关系。本研究的目的是评估口腔白斑病和口腔扁平苔藓患者口腔中幽门螺杆菌DNA的存在情况。
该研究纳入了54例口腔白斑病患者、72例口腔扁平苔藓患者以及40名健康对照者。采用单步聚合酶链反应（PCR）方法分析口腔样本中幽门螺杆菌的存在情况。所有患者均接受了牙周检查，并收集了以下临床参数：牙周袋深度、出血情况和菌斑指数。使用奥芬巴赫分类法评估牙周状况。
大多数患者的病理病变位于颊黏膜的典型部位（88%的白斑病患者和93%的扁平苔藓患者）。幽门螺杆菌DNA在20%的白斑病患者和23%的扁平苔藓患者中存在。我们在健康对照者中未发现幽门螺杆菌DNA。研究组的牙周指数所描述的牙周状况比对照组更差。
这些发现表明口腔中幽门螺杆菌的存在可能与口腔白斑病和扁平苔藓病变有关。
