来自昆虫病原真菌——拟细脚虫草BCC 1620的双蒽类化合物。I. 分类学、发酵、分离及抗疟活性
Bioxanthracenes from the insect pathogenic fungus. Cordyceps pseudomilitaris BCC 1620. I. Taxonomy, fermentation, isolation and antimalarial activity.
作者信息
Jaturapat A, Isaka M, Hywel-Jones N L, Lertwerawat Y, Kamchonwongpaisan S, Kirtikara K, Tanticharoen M, Thebtaranonth Y
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Bangkok, Thailand.
出版信息
J Antibiot (Tokyo). 2001 Jan;54(1):29-35. doi: 10.7164/antibiotics.54.29.
PMID:11269712
Abstract
Eleven bioxanthracenes and two monomers, six novel in nature, were isolated from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620. Growth optimization of the strain led to the improvement of bioxanthracenes production. The bioxanthracenes were evaluated for their antimalarial activity and cytotoxicity.
摘要
从昆虫病原真菌蛹虫草BCC 1620中分离出11种双蒽酮类化合物和2种单体，其中6种是新的天然产物。该菌株的生长优化提高了双蒽酮类化合物的产量。对这些双蒽酮类化合物的抗疟活性和细胞毒性进行了评估。
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