Cruz T, Gálvez J, Crespo E, Ocete M A, Zarzuelo A
Planta Med. 2001 Feb;67(1):94-6. doi: 10.1055/s-2001-10620.
The intestinal anti-inflammatory activity of several doses of silymarin was tested in the acute stage of the trinitrobenzenesulfonic acid (TNBS) model of rat colitis. The results obtained show that oral pre-treatment with 50 mg/kg of silymarin significantly attenuated macroscopic colonic damage as well as reduced colonic myeloperoxidase activity compared to non-treated colitic animals. The beneficial effect was accompanied by an improvement in the colonic oxidative status, which was altered in colonic inflammation, by preventing glutathione depletion and reducing malonyldialdehyde production. This suggests that the well known antioxidant properties of silymarin can participate in its intestinal anti-inflammatory activity. In addition, a preservation in the colonic absorptive function was also observed, and this effect can also account for the colonic protective effect observed in this model of acute colitis.
在大鼠结肠炎的三硝基苯磺酸（TNBS）模型急性期，测试了几剂水飞蓟素的肠道抗炎活性。所得结果表明，与未治疗的结肠炎动物相比，口服50mg/kg水飞蓟素预处理可显著减轻结肠宏观损伤，并降低结肠髓过氧化物酶活性。这种有益作用伴随着结肠氧化状态的改善，结肠炎症时氧化状态会发生改变，这是通过防止谷胱甘肽耗竭和减少丙二醛生成来实现的。这表明水飞蓟素众所周知的抗氧化特性可参与其肠道抗炎活性。此外，还观察到结肠吸收功能得以保留，这种作用也可解释在该急性结肠炎模型中观察到的结肠保护作用。
